The SMU Mustangs (2-2) host an ACC battle against the Syracuse Orange (3-2) on Saturday, October 4, 2025 at Gerald J. Ford Stadium.

The Mustangs are very heavy favorites (currently -17.5) in their game against the Orange, with the over/under at 57.5 points. (In terms of the moneyline, the Mustangs are -813 and the Orange are +559.)

Below you can find our betting preview for this this contest between the Mustangs and the Orange, and find all of our expert picks here, too!

SMU vs. Syracuse betting lines

• Spread favorite: Mustangs (-17.5)
• Moneyline: Mustangs (-813), Orange (+559)
• Total: 57.5 points
• TV Channel: ACC Network
• Live Stream: Fubo

SMU vs. Syracuse betting info and stats

SMU has not won a game against the spread so far this season (0-3-0). SMU has yet to cover the spread when the favorite by at least 17.5 points (a 0-1 ATS record). SMU split the two games it has played as the moneyline favorite this season. Syracuse has won two games against the spread so far this season (2-2-1). In the one game Syracuse has been an underdog by at least 17.5 points this season, it has covered the spread. This is the fourth time this year Syracuse is an underdog on the moneyline and has gone 1-2 in such contests.

SMU vs. Syracuse recent stats and trends

SMU Mustangs

Syracuse Orange

• Syracuse is 2-1 against the spread over its past three games and has a 1-2 straight-up record in those matchups.
• Syracuse and its opponents have hit the over two times in those games.
• Syracuse’s last three outings have ended with an average of 59.5 points scored. That’s 2.0 more points than this contest’s over/under.

SMU vs. Syracuse key players

SMU Mustangs

• Kevin Jennings has compiled 1,126 yards (281.5 ypg) on 86-of-126 passing with nine touchdowns compared to five interceptions this season.
• Tomarion Harden has 309 rushing yards on 57 carries with five touchdowns.
• This season, Chris Johnson Jr. has carried the ball 23 times for 130 yards (32.5 per game) and one touchdown, while also racking up 82 yards through the air.
• Romello Brinson’s 365 yards as a receiver lead the team. He’s been targeted 24 times and has collected 19 catches and three touchdowns.
• Jalen Cooper has caught 13 passes for 243 yards (60.8 yards per game) and two touchdowns this year.
• Yamir Knight has a total of 133 receiving yards so far this year, hauling in 12 passes and scoring one touchdown.
• Cam Robertson paces the team with 3.0 sacks, and also has 3.0 TFL and 14 tackles.
• Isaiah Nwokobia, SMU’s leading tackler, has 19 tackles and one interception this year.
• Jaelyn Davis-Robinson leads the team with two interceptions, while also putting up eight tackles and two passes defended.

Syracuse Orange

• Steve Angeli leads Syracuse with 1,352 yards on 98-of-156 passing with 10 touchdowns compared to two interceptions this season.
• The team’s top rusher, Yasin Willis, has carried the ball 63 times for 296 yards (74.0 per game) with four touchdowns.
• Will Nixon has piled up 200 yards (on 47 attempts) with two touchdowns, while also grabbing 11 passes for 99 yards.
• Darrell Gill Jr. has collected 16 catches this season and his team-high yardage total sits at 329 (65.8 yards per game). He’s been targeted 28 times and has three touchdowns.
• Johntay Cook II has 24 receptions (on 38 targets) for a total of 308 yards (61.6 yards per game) and one touchdown this year.
• Dan Villari’s 22 receptions (on 30 targets) have netted him 250 yards (50.0 ypg).
• Braheem Long Jr. has racked up 2.0 sacks to pace the team, while also recording 2.0 TFL, 18 tackles, and one interception.
• Darian Chestnut is the team’s top-tackler this year. He’s racked up 25 tackles.
• Long has a team-high one interception to go along with 18 tackles, 2.0 TFL, two sacks, and one pass defended.