The No. 11 South Carolina Gamecocks (2-0) take on a fellow SEC foe when they host the Vanderbilt Commodores (2-0) on Saturday, September 13, 2025 at Williams-Brice Stadium.

The Gamecocks are the favorites (-3) in their game against the Commodores, with the over/under being 48.5 points. (On the moneyline, the Gamecocks are -151 and the Commodores are +126.)

Keep reading to check out our betting preview for this this matchup between the Gamecocks and the Commodores, and find all of our predictions here, too!

South Carolina vs. Vanderbilt betting lines

• Spread favorite: Gamecocks (-3)
• Moneyline: Gamecocks (-151), Commodores (+126)
• Total: 48.5 points
• TV Channel: SEC Network
• Live Stream: Fubo

South Carolina vs. Vanderbilt betting info and stats

South Carolina, in two games with a spread this season, is 1-1-0 against the spread. South Carolina is 1-1 ATS when the favorite by at least 3 points. In one game as a moneyline favorite, South Carolina won. Vanderbilt has a pair of wins against the spread so far this season (2-0-0). Vanderbilt has played a game as the underdog on the moneyline in one game so far this season, and won that game.

South Carolina vs. Vanderbilt key players

South Carolina Gamecocks

• LaNorris Sellers has thrown for 337 yards (168.5 ypg) to lead South Carolina, completing 60.5% of his passes and recording two touchdown passes this season. He’s also contributed in the ground game with 48 rushing yards on 21 carries with one rushing touchdown.
• Oscar Adaway III has racked up 80 yards on 21 carries while finding paydirt one time as a runner.
• This season, Rahsul Faison has carried the ball 12 times for 61 yards (30.5 per game).
• Nyck Harbor has hauled in three receptions for 99 yards (49.5 yards per game) to lead the team so far this season. He’s found the end zone one time as a receiver.
• Donovan Murphree has put up a 60-yard season so far, reeling in three passes on five targets.
• Vandrevius Jacobs has racked up four receptions for 57 yards, an average of 57 yards per game. He’s scored one time as a receiver this season.
• Dylan Stewart leads the team with two sacks, and also has three TFL and 10 tackles.
• Fred Johnson has been all over the field, leading the team in both tackles and interceptions. He has 12 tackles and one interception so far.

Vanderbilt Commodores

• Diego Pavia has thrown for 468 yards (234 yards per game) while completing 74.4% of his passes and recording five touchdown passes with one interception this season. He’s also rushed for 105 yards .
• Sedrick Alexander has rushed 22 times for 156 yards, with two touchdowns.
• Makhilyn Young has piled up 11 carries and totaled 114 yards with two touchdowns.
• Tre Richardson’s 128 receiving yards (64 yards per game) lead the team. He has eight catches on 10 targets with one touchdown.
• Eli Stowers has put together a 115-yard season so far with one touchdown. He’s caught eight passes on eight targets.
• Junior Sherrill’s five receptions (on seven targets) have netted him 65 yards (32.5 ypg) and one touchdown.
• Hayden Bray paces the team with one sack, and also has one TFL.
• Bryan Longwell, Vanderbilt’s top tackler, has eight tackles and one TFL this year.
• CJ Heard has a team-high one interception to go along with five tackles, one TFL, one sack, and one pass defended.