The Tulane Green Wave (2-0) and the Duke Blue Devils (1-1) meet at Yulman Stadium on Saturday, September 13, 2025.

The Green Wave are favored, but by less than a field goal (-1.5), against the Blue Devils. The over/under for this game is 52.5 points.

Read on for our betting preview for this this game between the Green Wave and the Blue Devils, and uncover all of our predictions here, too!

Tulane vs. Duke betting lines

• Spread favorite: Green Wave (-1.5)
• Moneyline: Green Wave (-120), Blue Devils (+100)
• Total: 52.5 points
• TV Channel: ESPN2
• Live Stream: Fubo

Tulane vs. Duke betting info and stats

Tulane, in two games with a spread so far this season, has gone 1-1-0 against the spread. Tulane has covered the spread in one game when the favorite by at least 1.5 points (a 1-1 ATS record). Tulane won both of the games it has played as the moneyline favorite this season. Duke, in two games with a set spread so far this season, has gone 0-2-0 against the spread. When Duke is an underdog of 1.5 points or more, it has have yet to cover the spread. This will be the second game this year Duke is the moneyline underdog. The Blue Devils lost the first one.

Tulane vs. Duke key players

Tulane Green Wave

• Jake Retzlaff has been a dual threat for Tulane so far this season. He has 277 passing yards, completing 56.4% of his passes and collecting two touchdown passes this season. He’s rushed for 177 yards (88.5 ypg) on 23 carries with two rushing touchdowns.
• Javin Gordon has carried the ball 20 times for 104 yards (52 per game).
• Omari Hayes has hauled in nine receptions for 74 yards (37 yards per game) to lead the team so far this season. .
• Bryce Bohanon has hauled in six passes while averaging 32.5 yards per game.
• Justyn Reid has a total of 52 receiving yards so far this year, grabbing four throws and scoring one touchdown.
• Santana Hopper leads the team with one sack, and also has one TFL and five tackles.
• Tulane’s leading tackler, Jack Tchienchou, has 15 tackles, one TFL, and one sack this year.
• Javion White leads the team with two interceptions, while also putting up three tackles and two passes defended.

Duke Blue Devils

• Darian Mensah leads Duke with 723 yards on 50-of-68 passing with five touchdowns compared to one interception this season.
• Anderson Castle has run the ball seven times for 80 yards.
• Jaquez Moore has totaled 74 yards on 13 carries with one touchdown, while also catching four passes for 44 yards.
• Cooper Barkate has racked up 205 receiving yards on nine receptions to pace his squad so far this season.
• Sean Brown has recorded 110 receiving yards (55 yards per game) on seven receptions.
• Andrel Anthony has racked up 109 reciving yards (54.5 ypg) and three touchdowns this season.
• Vincent Anthony Jr. leads the team with four sacks, and also has four TFL and nine tackles.
• Duke’s leading tackler, Caleb Weaver, has 13 tackles this year.