Guardians vs. White Sox Betting Lines, Odds, & Player Matchups September 13, 2025

Data Skrive
Data Skrive

The Cleveland Guardians (76-71) host the Chicago White Sox (57-91) on Saturday at 6:10 p.m. ET. The Guardians are favored (-167) against the underdog White Sox (+141). Parker Messick takes the mound first for Cleveland, and Davis Martin is Chicago’s pick to start.

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Moneyline

Guardians to win vs White Sox -167

Bet $20, Payout $31.98

Guardians vs. White Sox betting lines

  • Favorite: Guardians (-167)
  • Underdog: White Sox (+141)
  • Over/under: 8

Guardians betting info, hitting leaders, & pitching

Guardians betting info

  • The Guardians have compiled a 38-24 record in games they were listed as the moneyline favorite (winning 61.3% of those games).
  • Cleveland has a 7-2 record (winning 77.8% of its games) when it has played as moneyline favorites of -167 or shorter.
  • Based on this matchup’s moneyline, the Guardians have an implied win probability of 62.5%.
  • Cleveland has had an over/under set by bookmakers 145 times, and have combined with opponents to go over the total in 62 of those games (62-76-7).
  • The Guardians have a 75-70-0 record against the spread this season (covering 51.7% of the time).

Guardians hitting info

  • Jose Ramirez paces the Guardians with 28 home runs and 77 runs batted in, while racking up a team-best batting average of .283.
  • Ramirez’s home runs rank 21st in MLB and he ranks 44th in RBI in MLB.
  • Steven Kwan has 26 doubles, a triple, 10 home runs and 51 walks while batting .275.
  • Among all MLB hitters, Kwan ranks 193rd in home runs and 169th in RBI.
  • Kyle Manzardo is hitting .239 with 15 doubles, two triples, 26 home runs and 46 walks.
  • Angel Martinez is hitting .226 with 21 doubles, a triple, 11 home runs and 19 walks.

Guardians pitching rankings

  • The pitching staff for the Guardians has a collective 8.4 K/9, which ranks 16th in MLB.
  • Cleveland’s 3.84 team ERA ranks eighth among all MLB pitching staffs.
  • The Guardians average baseball’s 18th-ranked WHIP (1.295).
  • Guardians pitchers combine to give up 156 home runs (1.1 per game), the ninth-fewest in MLB.
  • Cleveland knocked off the White Sox 4-0 in its last game with 10 strikeouts while allowing two hits.

White Sox betting info, hitting leaders, & pitching

White Sox betting info

  • This season, the White Sox have won 56 out of the 146 games, or 38.4%, in which they’ve been the underdog.
  • Chicago is 25-54 this season when entering a game as the underdog by +141 or more on the moneyline.
  • The implied probability of a win by the White Sox, based on the moneyline, is 41.5%.
  • Chicago and its opponents have hit the over in 68 of its 148 games with a total this season.
  • The White Sox have an ATS record of 87-61-0 in 148 games with a spread this season.

White Sox hitting info

  • Miguel Vargas has been key for Chicago with 105 hits, an OBP of .314 plus a slugging percentage of .399.
  • Vargas’ home run total ranks 140th in the majors, and he is 141st in RBI.
  • Andrew Benintendi has collected 100 hits this season and has an OBP of .309. He’s slugging .435 on the year.
  • Benintendi is 78th overall in home runs and 104th in RBI this season.
  • Lenyn Sosa leads Chicago in batting average (.263), home runs (20) and runs batted in (67) this season.
  • Chase Meidroth is batting .269 with an OBP of .348 and a slugging percentage of .338 this season.
  • Meidroth has hit safely in eight straight games. During his last 10 games he is hitting .429 with a double, a home run, five walks and three RBIs.

White Sox pitching rankings

  • The White Sox strike out eight batters per nine innings as a pitching staff, 22nd in MLB.
  • Chicago has the 20th-ranked ERA (4.23) in the majors this season.
  • The White Sox have a combined WHIP of 1.364 as a pitching staff, which ranks 25th in MLB.
  • With 168 homers allowed, the White Sox rank 14th in the league at preventing long balls.
  • Last time out, Chicago fell to the Guardians 4-0. Its pitchers compiled three strikeouts and six hits allowed.
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