Big Ten foes match up when the No. 25 USC Trojans (3-0) and the Michigan State Spartans (3-0) play on Saturday, September 20, 2025 at Los Angeles Memorial Coliseum.

The Spartans are expected to lose by at least two TDs (currently +18.5) versus the Trojans (with an over/under of 55.5 points).

Below you’ll find our preview for this this contest between the Trojans and the Spartans, and uncover all of our predictions here, too!

USC vs. Michigan State betting lines

• Spread favorite: Trojans (-18.5)
• Moneyline: Trojans (-990), Spartans (+636)
• Total: 55.5 points
• TV Channel: FOX 4K
• Live Stream: Fubo

USC vs. Michigan State betting info and stats

USC, in three games with a spread so far this season, has gone 2-1-0 against the spread. USC is 2-1 ATS when favored by at least 18.5 points. In three games as the moneyline favorite, USC has gone 3-0. Michigan State has not won a game against the spread so far this season (0-3-0). This will be the first time on the year Michigan State is an underdog on the moneyline.

USC vs. Michigan State key players

USC Trojans

• Jayden Maiava has recorded 989 yards (329.7 ypg) on 48-of-70 passing with six touchdowns compared to zero interceptions this season.
• Waymond Jordan has carried the ball 39 times for a team-high 286 yards on the ground and has found the end zone three times as a runner.
• Eli Sanders has carried the ball 23 times for 160 yards (53.3 per game) and two touchdowns while also racking up 88 yards through the air, scoring one time.
• Makai Lemon’s team-high 311 yards as a receiver have come on 16 receptions (out of 21 targets) with two touchdowns.
• Ja’Kobi Lane has put up a 239-yard season so far with one touchdown, hauling in nine passes on 13 targets.
• Lake McRee has hauled in seven receptions for 173 yards, an average of 57.7 yards per game. He’s scored one time as a receiver this season.
• Eric Gentry, the team’s tackle and sacks leader, has racked up three sacks, two TFL and 10 tackles.
• Bishop Fitzgerald has picked off a team-high three passes. He also has five tackles and three passes defended to his name.

Michigan State Spartans

• Aidan Chiles has thrown for 656 yards on 58-of-81 passing with six touchdowns and one interception this season. He has chipped on the ground, as well, with 123 yards and one rushing touchdown.
• Makhi Frazier has run for 206 yards on 43 carries so far this year while scoring two times on the ground.
• Nick Marsh has totaled 16 catches this season and his team-high yardage total sits at 194 (64.7 yards per game). He’s been targeted 22 times and has three touchdowns.
• Omari Kelly has put together a 184-yard season so far. He’s caught 15 passes on 21 targets.
• Michael Masunas’ six catches (on six targets) have netted him 81 yards (27 ypg) and two touchdowns.
• Anelu Lafaele has two sacks to lead the team, and also has one TFL and three tackles.
• Michigan State’s leading tackler, Jordan Hall, has 26 tackles, three TFL, and two sacks this year.
• Wayne Matthews III leads the team with one interception, while also recording 23 tackles and one pass defended.