The Purdue Boilermakers (2-1) visit the No. 24 Notre Dame Fighting Irish (0-2) at Notre Dame Stadium on Saturday, September 20, 2025.
The Boilermakers are expected to lose by at least two TDs (currently +24.5) versus the Fighting Irish (with an over/under of 51.5 points).
Read on for our betting preview for this this matchup between the Fighting Irish and the Boilermakers, and uncover all of our expert picks here, too!
To Cover the Spread
Bet $20, Payout $37.86
Notre Dame -24.5 vs. Purdue
Notre Dame vs. Purdue betting lines
- Spread favorite: Fighting Irish (-24.5)
- Moneyline: Fighting Irish (-2857), Boilermakers (+1256)
- Total: 51.5 points
- TV Channel: NBC (WBGH-Binghamton, NY)
- Live Stream: Fubo
Notre Dame vs. Purdue betting info and stats
- Notre Dame has yet to win a game against the spread so far this season (0-2-0). Notre Dame lost both of the games it has played as the moneyline favorite this season. Purdue has won twice against the spread this season (2-1-0). Purdue has played as the underdog on the moneyline in one game this season, and failed to pick up the victory.
Notre Dame vs. Purdue key players
Notre Dame Fighting Irish
- CJ Carr has thrown for 514 yards (257 ypg) to lead Notre Dame, completing 62.9% of his passes and tossing three touchdown passes compared to two interceptions this season.
- Jeremiyah Love has carried the ball 33 times for a team-high 127 yards (63.5 per game) with one score. He has also caught eight passes for 79 yards and one receiving touchdown.
- Jadarian Price has collected 113 yards on 18 carries, scoring two times.
- Eli Raridon’s leads his squad with 182 yards as a receiver. He’s racked up that yardage on nine catches (out of 13 targets).
- Malachi Fields has caught eight passes for 125 yards (62.5 yards per game) this year.
- Boubacar Traore has one sack to pace the team, and also has one TFL and six tackles.
- Jalen Stroman, Notre Dame’s tackle leader, has nine tackles this year.
- Leonard Moore has picked off a team-high one pass. He also has three tackles and one pass defended to his name.
Purdue Boilermakers
- Ryan Browne has been a dual threat for Purdue this season. He has 786 passing yards (262 per game) while completing 63.6% of his passes. He’s tossed five touchdown passes and four interceptions this season. On the ground, he’s compiled 59 yards (19.7 ypg) on 25 carries with two rushing touchdowns.
- Devin Mockobee has run for 230 yards on 58 carries so far this year while scoring three times on the ground. He’s also tacked on four catches, totaling 66 yards.
- Arhmad Branch has hauled in 167 receiving yards on seven catches to pace his team so far this season while scoring two touchdowns as a receiver.
- Michael Jackson III has collected 149 receiving yards (49.7 yards per game) and one touchdown on 14 receptions.
- Nitro Tuggle’s 12 targets have resulted in eight grabs for 130 yards and two touchdowns.
- CJ Nunnally has two sacks to lead the team, and also has two TFL and four tackles.
- Purdue’s tackle leader, Charles Correa, has 16 tackles, three TFL, and one sack this year.
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