The No. 3 Oregon Ducks (5-0) face a fellow Big Ten opponent when they host the No. 7 Indiana Hoosiers (5-0) on Saturday, October 11, 2025 at Autzen Stadium.

The Ducks are expected to win by at least a touchdown (currently -7) versus the Hoosiers. The over/under for this matchup is 53.5 points.

Keep reading for our betting preview for this this matchup between the Ducks and the Hoosiers, and find all of our betting picks here, too!

Oregon vs. Indiana betting lines

• Spread favorite: Ducks (-7)
• Moneyline: Ducks (-283), Hoosiers (+230)
• Total: 53.5 points
• TV Channel: CBS (KTVQ – Billings)
• Live Stream: Fubo

Oregon vs. Indiana betting info and stats

Oregon, through five games with a spread this season, is 3-2-0 against the spread. Oregon is 2-2 ATS when the favorite by at least 7 points. Oregon has been the moneyline favorite in three games this season, and it has put together a 3-0 record in those matchups. Indiana has won three games against the spread this season (3-2-0). This is the first game on the year Indiana is an underdog on the moneyline.

Oregon vs. Indiana recent stats and trends

Oregon Ducks

• Oregon has covered the spread once in its last three matchups while putting together a 3-0 record straight-up in those games.
• One time in those three games, the final combined score exceeded the set total.
• The past three Oregon games averaged 0.3 fewer points (53.2) than this matchup’s point total.

Indiana Hoosiers

• Indiana is 2-1 against the spread over its past three games and has a 3-0 straight-up record in those contests.
• Indiana and its opponents have combined to hit the over in two of those games.
• Indiana’s past three games have ended with an average of 53.2 points scored. That’s 0.3 fewer points than this contest’s over/under.

Oregon vs. Indiana key players

Oregon Ducks

• Dante Moore has 1,210 passing yards for Oregon, completing 74.6% of his passes and throwing 14 touchdowns and one interception this season. He’s also chipped in on the ground with 122 rushing yards (24.4 ypg) on 24 carries.
• Dierre Hill Jr. has racked up 270 yards on 26 carries while finding paydirt two times as a runner.
• This season, Jayden Limar has carried the ball 39 times for 232 yards (46.4 per game) and three touchdowns.
• Dakorien Moore has hauled in 19 catches for 296 yards (59.2 yards per game) to lead the team so far this season. He’s found the end zone two times as a receiver.
• Malik Benson has caught 16 passes for 212 yards (42.4 yards per game) and two touchdowns this year.
• Kenyon Sadiq has compiled 15 catches for 204 yards, an average of 40.8 yards per game. He’s scored three times as a receiver this season.
• Matayo Uiagalelei has collected 4.0 sacks to pace the team, while also picking up 5.0 TFL and 11 tackles.
• Bryce Boettcher, Oregon’s leading tackler, has 34 tackles and one interception this year.
• Jerry Mixon has a team-high two interceptions to go along with 13 tackles, 1.0 TFL, and two passes defended.

Indiana Hoosiers

• Fernando Mendoza has thrown for 1,208 yards (241.6 per game) while completing 73% of his passes and collecting 16 touchdown passes with one interception this season. He’s also run for 102 yards with two touchdowns.
• The team’s top rusher, Roman Hemby, has carried the ball 65 times for 351 yards (70.2 per game). He’s also caught five passes for 76 yards.
• Kaelon Black has run for 344 yards across 55 attempts, scoring two touchdowns.
• Omar Cooper Jr. has racked up 432 receiving yards on 23 receptions to pace his squad so far this season while scoring six touchdowns as a receiver.
• Elijah Sarratt has put up a 388-yard season so far with six touchdowns. He’s caught 30 passes on 41 targets.
• E.J. Williams’ 22 targets have resulted in 14 grabs for 153 yards and two touchdowns.
• Isaiah Jones has 3.5 sacks to pace the team, and also has 6.0 TFL and 19 tackles.
• Indiana’s tackle leader, Louis Moore, has 23 tackles, 2.0 TFL, and two interceptions this year.
• Amare Ferrell has picked off a team-high three passes. He also has 12 tackles, 1.0 TFL, and three passes defended to his name.