The No. 10 Alabama Crimson Tide (8-2) take on an FCS opponent, the Eastern Illinois Panthers (3-8), on Saturday, November 22, 2025 at Bryant-Denny Stadium.

The Crimson Tide are expected to win by at least two TDs (currently -50.5) versus the Panthers. The over/under for this matchup is 57.5 points.

Read on for our betting primer for this this game between the Crimson Tide and the Panthers, and discover all of our betting picks here, too!

Alabama vs. Eastern Illinois betting lines

• Spread favorite: Crimson Tide (-50.5)
• Moneyline: Crimson Tide (), Panthers ()
• Total: 57.5 points

Alabama vs. Eastern Illinois betting info and stats

Alabama is 6-4-0 against the spread in 10 opportunities this season. In the nine games favored on the moneyline, Alabama has put together a 7-2 record. Eastern Illinois has a 6-5-0 record against the spread so far this season. In the nine games this year, Eastern Illinois has been the moneyline underdog, it is 1-8.

Alabama vs. Eastern Illinois recent stats and trends

Alabama Crimson Tide

• Alabama is 1-2 against the spread and 2-1 overall over its past three matchups.
• Once in those three games, the final combined score went over the set total.
• Alabama’s last three games have ended with an average of 47.7 points scored. That’s 9.8 fewer points than this contest’s over/under.

Eastern Illinois Panthers

• Eastern Illinois is 1-2 against the spread and 2-1 overall over its last three games.
• Eastern Illinois and its opponents have combined to hit the over once in those games.
• The past three Eastern Illinois games averaged 7.0 fewer points (50.5) than this matchup’s over/under.

Alabama vs. Eastern Illinois key players

Alabama Crimson Tide

• Ty Simpson has compiled 2,787 yards (278.7 ypg) on 226-of-338 passing with 22 touchdowns compared to two interceptions this season.
• Jamarion Miller has racked up 348 yards on 97 carries while finding paydirt two times as a runner.
• Kevin Riley has piled up 186 yards on 48 attempts. He’s caught 16 passes for 139 yards (19.9 per game) and one touchdown, as well.
• Germie Bernard’s team-leading 676 yards as a receiver have come on 48 receptions (out of 82 targets) with six touchdowns.
• Ryan Williams has grabbed 39 passes while averaging 63.7 yards per game and scoring four touchdowns.
• Isaiah Horton has hauled in 27 receptions for 354 yards, an average of 39.3 yards per game. He’s scored five times as a receiver this season.
• Yhonzae Pierre leads the team with 6.0 sacks, and also has 8.0 TFL and 31 tackles.
• Justin Jefferson, Alabama’s leading tackler, has 54 tackles, 3.0 TFL, two sacks, and one interception this year.
• Bray Hubbard leads the team with three interceptions, while also collecting 43 tackles, 1.0 TFL, and three passes defended.

Eastern Illinois Panthers

• Connor Wolf leads Eastern Illinois with 1,054 yards on 83-of-139 passing with eight touchdowns compared to four interceptions this season.
• The team’s top rusher, Charles Kellom, has carried the ball 178 times for 691 yards (62.8 per game) with three touchdowns.
• Cole LaCrue has racked up 514 yards on 122 carries with seven touchdowns.
• CJ Nelson’s 393 receiving yards (49.1 yards per game) are best on his team. He has 22 receptions on 21 targets with three touchdowns.
• DeAirious Smith has caught 27 passes and compiled 365 receiving yards (36.5 per game) with three touchdowns.
• Cooper Willman’s 20 targets have resulted in 23 receptions for 333 yards and three touchdowns.
• Samuel Robles has collected 4.0 sacks to lead the team, while also picking up 43 tackles, 1.0 TFL, and three passes defended.
• Trevon Piggee-Blake is the team’s leading tackler this year. He’s totaled two sacks.
• Moses Alexander has a team-leading three interceptions to go along with two sacks.