Alvin Kamara and his New Orleans Saints teamates will hit the field against the Buffalo Bills at 1 p.m. ET on Sunday in Week 4 of the 2025 NFL season. In this article we dig into all of Kamara’s prop bets set for this contest, and examine the stats to figure out the best predictions.

Alvin Kamara Prop Lines

• Matchup: New Orleans Saints at Buffalo Bills
• Time: 1 p.m. ET
• Date: September 28, 2025
• Rushing yards prop: Over 49.5 (-115)
• Receiving yards prop: Over 19.5 (-115)

Alvin Kamara Stats and Trends

• Kamara has picked up a team-high 186 yards on 50 carries (62.0 ypg). He has scored one TD on the ground.
• Kamara runs for 62.0 yards per game, which is better than Sunday’s prop total of 49.5.
• This season Kamara has bettered this week’s over/under for rushing yards (49.5) once.
• His rushing yards average of 62.0 is 5.5 higher than his over/under average (56.5).
• One time in three opportunities this season, Kamara has bettered his rushing yards over/under.
• He has one rushing TD this year.
• Kamara has also made a difference in the air attack, grabbing nine balls for 47 yards (15.7 ypg).

Recent Performances vs. the Bills

Saints Away Splits (Last Season)

• On the road last year, the Saints scored fewer points (18 per game) than overall (19.9). They also allowed more (24 per game) than overall (23.4).
• The Saints picked up 323.9 yards per game away from home (3.8 more than overall) and conceded 359.5 in road games (20.4 fewer than overall).
• The Saints accumulated more passing yards in away games last season (210.9 per game) than they did overall (205.2), and allowed fewer in road games (237.5 per game) than overall (238.5).
• The Saints picked up 113 rushing yards per game on the road (1.9 fewer than overall), and gave up 122 rushing yards in road games (19.4 fewer than overall).
• The Saints converted fewer third downs away from home in 2024 (34.7%) than they did overall (35.2%), but also allowed opponents to convert on fewer third downs away from home (40.7%) than overall (41.1%).