AS Roma vs. Lazio Betting Lines, Odds, & Offensive Leaders September 21, 2025

Data Skrive
Data Skrive

AS Roma (+158 to win) and Lazio (+177) — both coming off lossees — will play on Sunday in Serie A. Roma fell to Torino FC last time out, 1-0, and Lazio was beaten by Sassuolo 1-0.

Check out all the Latest Serie A Betting Previews!

Moneyline

AS Roma to win vs Lazio +158

Bet $20, Payout $51.60

AS Roma vs. Lazio Odds & Favorites

  • Favorite: AS Roma (+158)
  • Underdog: Lazio (+177)
  • Over/under: 2.5

AS Roma vs. Lazio Betting Insights

  • With two goals in 3 games, Roma is 12th in Serie A in scoring, while Lazio has given up three goals, ranking ninth.
  • Roma has been favored in three matches this season, and won twice.
  • Roma (+158) has been at least this big a favorite in three games, and won two.
  • Roma has a 38.8% chance of winning this match, based on the moneyline.
  • Lazio ranks sixth in Serie A in scoring so far this season (four goals, 1.3 per game), and Roma is first in goals conceded at one total and 0.3 per match.
  • Lazio has not won in one match as an underdog this season.
  • This season Lazio (+177) has been at least this big an underdog in one game, and won none.
  • According to the moneyline, Lazio’s chances of winning this match are 36.1%.
  • Not once this season has Roma and its opponent combined for more than 2.5 goals.
  • The two teams average a combined two goals per contest, 0.5 fewer than the total for this matchup.
  • Lazio’s games have gone over 2.5 goals on one occasion this year.
  • The total for this game is 2.5 goals, 1.2 higher than the combined goals allowed for these two teams.

AS Roma vs. Lazio Offensive Leaders

AS Roma Offensive Leaders

  • Matias Soule has taken a team-high nine shots (second in league) for Roma, and scored one goal.
  • Evan Ferguson is another top shot-taker for Roma (four), and has turned that into zero goals.
  • Soule also leads Roma in chances created with seven (third in league).

Lazio Offensive Leaders

  • Lazio’s Valentin Castellanos has four shots (27th in league) and one goal (seventh) this season.
  • Lazio has gotten four shots and one goal from Mattia Zaccagni.
  • Nuno Tavares is tops on Lazio in chances created with five (15th in league, 1.7 per game).
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