Orioles vs. Guardians Betting Lines, Odds, & Player Matchups April 16, 2025

Data Skrive
Data Skrive

The Baltimore Orioles (6-10) and the Cleveland Guardians (9-7) square off on Wednesday at 6:35 p.m. ET. The Orioles are moneyline favorites (-136) against the underdog Guardians (+116). Dean Kremer gets the starting nod for Baltimore, and Gavin Williams is Cleveland’s pick to start.

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Odds to Win

Orioles to win vs Guardians -136

Bet $20, Payout $34.71

Orioles vs. Guardians betting lines

  • Favorite: Orioles (-136)
  • Underdog: Guardians (+116)
  • Over/under: 8.5

Orioles betting info, hitting leaders, & pitching

Orioles betting info

  • The Orioles have a 2-5 record in games they were listed as the moneyline favorite (winning 28.6% of those games).
  • When playing as moneyline favorites with odds of -136 or shorter, Baltimore has a record of 1-2 (33.3%).
  • The Orioles have an implied moneyline win probability of 57.6% in this contest.
  • Baltimore has played in 16 games with set over/under, and have combined with opponents to go over the total nine times (9-5-2).
  • The Orioles have put together a 5-11-0 record against the spread this season (covering only 31.2% of the time).

Orioles hitting info

  • Cedric Mullins leads the Orioles in home runs (four), runs batted in (17) and has racked up a team-high batting average of .300.
  • Among hitters in MLB, Mullins ranks 26th in homers and sixth in RBI.
  • Adley Rutschman is batting .237 with two doubles, three home runs and seven walks.
  • Rutschman ranks 49th in home runs among hitters in MLB action and 139th in RBI.
  • Tyler O’Neill has three doubles, a triple, two home runs and four walks while batting .265.
  • Ryan O’Hearn is hitting .275 with three doubles, a home run and five walks.
  • O’Hearn has safely hit in two straight games. In his last five games he is hitting .214 with two walks.

Orioles pitching rankings

  • The pitching staff for the Orioles has a collective 7.2 K/9, the third-worst in MLB.
  • Baltimore has a 4.66 team ERA that ranks 25th among all MLB pitching staffs.
  • The Orioles have the fourth-highest WHIP in MLB (1.446).
  • The Orioles give up the seventh-fewest home runs in baseball (16 total, 1.0 per game).
  • Baltimore fell to the Guardians 6-3 in its last game with four strikeouts while allowing 11 hits.

Guardians betting info, hitting leaders, & pitching

Guardians betting info

  • This season, the Guardians have been the underdog eight times and won three of those games.
  • Cleveland has a record of 2-3 in games where bookmakers have it as underdogs of at least +116 on the moneyline.
  • The Guardians have a 46.3% chance to win this game based on the implied probability of the moneyline.
  • Cleveland and its opponents have gone over the total this season in seven of its 16 opportunities.
  • The Guardians are 7-9-0 against the spread in their 16 chances this season.

Guardians hitting info

  • Steven Kwan leads Cleveland in runs batted in with 11 while batting .333, which is also best on the team.
  • Kwan ranks 49th in homers and 32nd in RBI among all hitters in MLB.
  • Kwan has safely hit in five straight games. In his last five games he is hitting .391 with two home runs, a walk and eight RBI.
  • Jose Ramirez’s four home runs are most among Cleveland batters. He’s driven in eight runs this season while slugging .519.
  • Ramirez ranks 26th in home runs and 82nd in RBI among all hitters in MLB.
  • Kyle Manzardo leads Cleveland in home runs (four) and runs batted in (11) this season while batting .176.
  • Carlos Santana has 15 hits and an OBP of .319 to go with a slugging percentage of .377 this season.
  • Santana has hit safely in two games in a row. During his last five outings he is batting .158 with three walks and an RBI.

Guardians pitching rankings

  • The Guardians average 8.8 strikeouts per nine innings as a pitching staff, 10th-most in the big leagues.
  • Cleveland pitchers have a combined ERA of 3.56 ERA this year, seventh-best in baseball.
  • The Guardians have a combined WHIP of 1.331 as a pitching staff, which ranks 20th in MLB.
  • The Guardians have given up the 12th-fewest long balls so far this season with 17 home runs allowed.
  • Last time out, Cleveland defeated the Orioles, 6-3, with 12 strikeouts and eight hits allowed.
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