Orioles vs. Astros Betting Lines, Odds, & Player Matchups August 21, 2025

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Data Skrive

Bookmakers don’t expect the Houston Astros (69-57), at -109 on the moneyline, to stop their three-game losing streak when they square off against the Baltimore Orioles (59-67), at -110, on Thursday at 7:15 p.m. ET. Baltimore’s Brandon Young starts against Houston’s Jason Alexander.

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Money Line

Orioles to win vs Astros -110

Bet $20, Payout $38.18

Orioles vs. Astros betting lines

  • Favorite: Orioles (-110)
  • Underdog: Astros (-109)
  • Over/under: 9

Orioles betting info, hitting leaders, & pitching

Orioles betting info

  • The Orioles have won 46.6% of the games this season when they were the moneyline favorite (27-31).
  • When it has played as moneyline favorites with odds of -110 or shorter, Baltimore has a record of 27-32 (45.8%).
  • The implied moneyline probablility for this matchup gives the Orioles a 52.4% chance to win.
  • Baltimore has combined with opponents to hit the over on the total 53 times this season for a 53-69-4 record against the over/under.
  • The Orioles have covered 47.6% of their games this season, going 60-66-0 against the spread.

Orioles hitting info

  • Gunnar Henderson has put up a team-high batting average of .281, and paces the Orioles in home runs (15) and runs batted in (57).
  • Among hitters in MLB action, Henderson ranks 96th in home runs and 77th in RBI.
  • Henderson brings a two-game hitting streak into this game. During his last five outings he is hitting .222 with a triple, a home run, four walks and six RBIs.
  • Jackson Holliday’s 15 home runs are a team-high mark.
  • Holliday currently ranks 96th in homers and 127th in RBI in the bigs.
  • Jordan Westburg has launched a team-best 15 home runs.
  • Adley Rutschman is batting .227 with 16 doubles, a triple, nine home runs and 37 walks.

Orioles pitching rankings

  • The Orioles pitching staff ranks 17th in MLB with a collective 8.4 strikeouts per nine innings.
  • Baltimore has a 4.65 team ERA that ranks 26th among all MLB pitching staffs.
  • Pitchers for the Orioles combine for the fifth-worst WHIP in the majors (1.379).
  • Orioles pitchers combine to give up 167 total home runs at a rate of 1.3 per game (25th-fewest in the majors).
  • In its 4-3 win last time out, Baltimore struck out eight Red Sox batters while allowing eight hits.

Astros betting info, hitting leaders, & pitching

Astros betting info

  • This season, the Astros have been the underdog 41 times and won 24, or 58.5%, of those games.
  • Houston has a record of 24-16 in games where bookmakers have it as underdogs of at least -109 on the moneyline.
  • Bookmakers have implied with the moneyline set for this matchup that the Astros have a 52.2% chance to win.
  • So far this season, Houston and its opponents have hit the over in 57 of its 126 games with a total.
  • The Astros are 62-64-0 ATS in their 126 games with a spread this season.

Astros hitting info

  • Jose Altuve leads Houston in home runs this season with 22 while driving in 64 runs.
  • In all of MLB, Altuve is 34th in homers and 54th in RBI.
  • Jeremy Pena leads Houston in batting with a .310 average while slugging 13 homers and driving in 45 runs.
  • Pena is 117th in homers and 141st in RBI among all hitters in the major leagues.
  • Yainer Diaz is slashing .252/.280/.413 this season for the Astros.
  • Carlos Correa has 111 hits and an OBP of .329 to go with a slugging percentage of .400 this season.
  • Correa heads into this matchup on a four-game hitting streak. In his last five games he is batting .263 with a double and an RBI.

Astros pitching rankings

  • The Astros average 9.5 strikeouts per nine innings as a pitching staff, most in the majors.
  • Houston has pitched to a 3.87 ERA this season, which ranks 12th in baseball.
  • The Astros have a combined WHIP of just 1.219 as a pitching staff, which is the fifth-best in baseball this season.
  • The Astros have given up the 19th-fewest long balls so far this season with 151 home runs allowed.
  • Last time out, Houston fell to the Tigers 1-0. Its pitchers compiled nine strikeouts and five hits allowed.
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Betting Guide

How Money Line Works?

Moneyline betting is by far the easiest way to place a sports wager. There are no point spreads to parse, no garbage-time free throws to ruin your betting day, and no last-minute meaningless touchdowns to take you from a winner to a loser.

How to Bet Odds

When we, as sports fans, learned our multiplication tables, we aced the number 7. Seven, 14, 21, 28, 35, 42 were easy because we all watched football on the weekends. Multiplication by sevens, then add a three, a six after a missed PAT.

How to Bet on NFL Games

Baseball is America’s pastime, but football is America’s crazed passion, with its weekly schedule of games, millions of television viewers across the country and the world, and the billion-dollar stadiums that serve as Sunday cathedrals in 32 American cities.

What is the Spread?

If you are a golfer or have ever played on a bowling team, think of a point spread like a handicap. It is a way for two teams of differing abilities to play each other on equal footing.  The better team, and the favorite in the game, gives a certain amount …