The Buffalo Bulls (0-1) play an FCS opponent, the Saint Francis (PA) Red Flash (0-1), on Saturday, September 6, 2025 at UB Stadium.

The Bulls are expected to come out on top by at least two touchdowns (currently -36.5) against the Red Flash. The over/under for this game is 49.5 points.

Keep reading to check out our betting primer for this this contest between the Bulls and the Red Flash, and find all of our predictions here, too!

Buffalo vs. Saint Francis (PA) betting lines

• Spread favorite: Bulls (-36.5)
• Moneyline: Bulls (-50000), Red Flash (+4000)
• Total: 49.5 points

Buffalo vs. Saint Francis (PA) betting info and stats

Buffalo has not lost a game against the spread this season (1-0-0). Buffalo has not played a game as the moneyline favorite. Saint Francis (PA) has won just one game against the spread so far this season (1-0-0). This is the second game this year Saint Francis (PA) is an underdog on the moneyline. The Red Flash lost the first one.

Buffalo vs. Saint Francis (PA) key players

Buffalo Bulls

• Last year CJ Ogbonna put up 2,381 passing yards — including a 56.5% completion percentage — with 19 touchdowns and five interceptions (183.2 yards per game). His rushing performance consisted of 122 carries for 346 yards and eight TDs.
• Last year, Al-Jay Henderson ran for 1,078 yards on 204 carries (82.9 yards per game) and scored nine times. Henderson also collected 19 catches for 238 yards and one score.
• In the previous year, Victor Snow grabbed 55 passes (on 80 targets) for 651 yards (50.1 per game). He also found the end zone six times.
• JJ Jenkins tacked on 536 yards on 36 grabs with four touchdowns. He was targeted 60 times, and averaged 41.2 receiving yards per game.
• Taji Johnson’s stat line last season: 243 receiving yards, 20 catches, two touchdowns, on 36 targets.
• Kobe Stewart’s hard work last season put together a stat line of 9.5 sacks, 7.0 TFL and 37 tackles.
• Shaun Dolac amassed 154 tackles, 12.0 TFL, six sacks, and five interceptions last year.

Saint Francis (PA) Red Flash

• Nick Whitfield Jr. threw for 1,033 yards and six touchdowns last season.
• DeMarcus McElroy compiled 657 rushing yards and three touchdowns on the ground during last year’s campaign.
• Markell Holman ran for six rushing touchdowns and 577 yards a year ago. Holman also was efficient as a receiver, tallying 20 receptions for 155 yards.
• Gavin Thomson averaged 66.1 yards on 4.2 receptions per game and racked up seven receiving touchdowns in 2024.
• Jayden Ivory had 355 receiving yards (35.5 ypg) in 2024.
• Last year Paul Tangelo collected 5.0 sacks, 2.0 TFL and four tackles.
• Fran Brown Jr. was a playmaker on defense last season with 14 tackles, 1.0 TFL, and one sack.
• Last year Trey McLeer intercepted one pass to go along with nine tackles and one pass defended.