The Stanford Cardinal (0-1) visit the BYU Cougars (1-0) at LaVell Edwards Stadium on Saturday, September 6, 2025.

The Cougars are expected to come out on top by at least two TDs (currently -20.5) against the Cardinal. The over/under for this matchup is 44.5 points.

Read on for our preview for this this matchup between the Cougars and the Cardinal, and find all of our expert predictions here, too!

BYU vs. Stanford betting lines

• Spread favorite: Cougars (-20.5)
• Moneyline: Cougars (-1667), Cardinal (+916)
• Total: 44.5 points
• TV Channel: ESPN
• Live Stream: Fubo

BYU vs. Stanford betting info and stats

BYU, in one game with a spread so far this season, is unbeaten (1-0-0) against the spread. In one game played when favored by at least 20.5 points, BYU covered the spread. In one game as the moneyline favorite, BYU won. Stanford, in one game with a set spread so far this season, is 0-1-0 against the spread. Stanford has played a game as an underdog on the moneyline in one game this season, and failed to pick up the victory.

BYU vs. Stanford key players

BYU Cougars

• Last year Jake Retzlaff had 2,898 passing yards (222.9 per game), a 57.6% completion percentage (212-for-368), 20 touchdowns, and only 12 interceptions. He also added 418 rushing yards on 100 carries with six rushing TDs (averaging 32.2 yards per game).
• Last season LJ Martin took 138 carries for 723 yards (55.6 per game) and scored seven touchdowns.
• In the previous year, Chase Roberts grabbed 51 passes (on 75 targets) for 805 yards (61.9 per game). He also found the end zone four times.
• Darius Lassiter also impressed receiving last year. He collected 45 receptions for 703 yards and four touchdowns. He was targeted 92 times.
• Keelan Marion’s stat line last year: 346 receiving yards, 24 catches, one touchdown, on 42 targets.
• Jack Kelly’s hard work last season produced a stat line of 5.0 sacks, 7.0 TFL, 48 tackles, and one interception.
• Isaiah Glasker was a wrecking ball on the field, collecting 64 tackles, 12.0 TFL, 3.5 sacks, and three interceptions last year.
• Tanner Wall intercepted three passes last year while also totaling 49 tackles and three passes defended.

Stanford Cardinal

• Ashton Daniels averaged 141.7 passing yards per outing and tossed 10 touchdowns last season. In addition, he tacked on 669 yards rushing with three touchdowns.
• Micah Ford rushed for 309 yards last season.
• Elic Ayomanor averaged 69.3 yards on 5.2 receptions per game and racked up six receiving touchdowns in 2024.
• Emmett Mosley V averaged 43.8 receiving yards on 6.1 targets per game in 2024, scoring six touchdowns.
• Sam Roush averaged 27.8 receiving yards per game on 4.4 targets per game a season ago.
• Last year David Bailey collected 6.0 sacks, 4.0 TFL and 30 tackles.
• Gaethan Bernadel had an impressive defensive performance last season with 73 tackles, 4.0 TFL, one sack, and one interception.
• Last year Collin Wright intercepted three passes to go along with 37 tackles, 1.0 TFL, and three passes defended.