Cubs vs. Padres Betting Lines, Odds, & Player Matchups April 16, 2025

Data Skrive
Data Skrive

Fernando Tatis Jr. leads the San Diego Padres (14-3) into a matchup against the Chicago Cubs (11-8) after his two-home run performance in a 10-4 win over the Cubs. The Cubs are favorites (-154) for this game against the underdog Padres (+129), which begins at 4:10 p.m. ET on Wednesday. Chicago has Matthew Boyd starting, while San Diego will counter with Nick Pivetta.

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Betting Odds

Cubs to win vs Padres -154

Bet $20, Payout $32.99

Cubs vs. Padres betting lines

  • Favorite: Cubs (-154)
  • Underdog: Padres (+129)
  • Over/under: 8.5

Cubs betting info, hitting leaders, & pitching

Cubs betting info

  • The Cubs are 6-2 in games they were favored on the moneyline (winning 75% of those games).
  • Chicago has gone 2-1 (winning 66.7% of its games) when it has played as moneyline favorites of -154 or shorter.
  • The implied moneyline probablility for this matchup gives the Cubs a 60.6% chance to win.
  • Chicago has played in 19 games with set over/under, and have combined with opponents to go over the total 13 times (13-5-1).
  • The Cubs are 11-8-0 against the spread this season.

Cubs hitting info

  • Kyle Tucker leads the Cubs in home runs (five) and runs batted in (18).
  • Tucker’s home runs rank 11th in MLB and he ranks fourth in RBI in MLB.
  • Carson Kelly has a double, a triple, four home runs and 11 walks while hitting .417.
  • Kelly ranks 26th in home runs among hitters in MLB and 17th in RBI.
  • Seiya Suzuki is hitting .292 with two doubles, a triple, four home runs and 11 walks.
  • Michael Busch is batting .310 to lead his team.
  • Busch enters this matchup on a three-game hitting streak. In his last five games he is batting .381 with two doubles, three home runs, a walk and seven RBI.

Cubs pitching rankings

  • The pitching staff for the Cubs has a collective 7.7 K/9, which ranks 25th in MLB.
  • Chicago’s 4.37 team ERA ranks 21st across all MLB pitching staffs.
  • The Cubs average MLB’s 25th-ranked WHIP (1.389).
  • Cubs pitchers combine to surrender the 24th-fewest home runs in baseball (22 total, 1.2 per game).
  • Chicago struck out six Padres batters while giving up 11 hits in a 10-4 loss in its last game.

Padres betting info, hitting leaders, & pitching

Padres betting info

  • This season, the Padres have been the underdog six times and won four of those games.
  • San Diego has played as an underdog of +129 or more once this season and lost that game.
  • Oddsmakers have implied with the moneyline set for this matchup that the Padres have a 43.7% chance to win.
  • San Diego and its opponents have gone over the total this season in eight of its 17 opportunities.
  • The Padres are 12-5-0 ATS in their 17 games with a spread this season.

Padres hitting info

  • Tatis is batting .361 with six home runs and 12 RBI. All three of those stats are best among San Diego hitters this season.
  • Among all hitters in MLB, Tatis’ home run total is second, and his RBI total is 20th.
  • Tatis heads into this game on a four-game hitting streak. In his last five games he is hitting .316 with four home runs, two walks and five RBI.
  • Manny Machado has collected 20 hits this season and has an OBP of .394. He’s slugging .476 on the year.
  • Among all major league hitters, Machado is 132nd in homers and 138th in RBI.
  • Machado heads into this game on a two-game hitting streak. During his last five outings he is hitting .313 with two doubles, five walks and an RBI.
  • Luis Arraez has collected 20 base hits, an OBP of .307 and a slugging percentage of .408 this season.
  • Arraez takes a three-game hitting streak into this game. In his last five games he is hitting .217 with a double, a home run and an RBI.
  • Xander Bogaerts is batting .288 with an OBP of .386 and a slugging percentage of .373 this season.

Padres pitching rankings

  • The Padres have an 8.9 K/9 this season as a pitching staff, eighth-best in baseball.
  • San Diego pitchers have a combined ERA of 2.70 ERA this year, second-best in baseball.
  • The Padres have a combined WHIP of just 1.073 as a pitching staff, which is the second-best in baseball this season.
  • With just 12 homers allowed, the Padres rank third in the league at preventing long balls.
  • San Diego pitchers struck out nine Cubs batters while allowing 11 hits in a 10-4 win last time out.
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Betting Guide

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Moneyline betting is by far the easiest way to place a sports wager. There are no point spreads to parse, no garbage-time free throws to ruin your betting day, and no last-minute meaningless touchdowns to take you from a winner to a loser.

How to Bet Odds

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