Levi’s Stadium features Week 4 action as the San Francisco 49ers and Christian McCaffrey face the Jacksonville Jaguars at 4:05 p.m. ET on Sunday. In this article, we take a look at all of McCaffrey’s prop bets set for this matchup, and examine the stats and insights to figure out the best bets and top trends before kickoff.

Christian McCaffrey Prop Lines

• Matchup: San Francisco 49ers vs. Jacksonville Jaguars
• Time: 4:05 p.m. ET
• Date: September 28, 2025
• Rushing yards prop: Over 72.5 (-113)
• Receiving yards prop: Over 43.5 (-113)

Christian McCaffrey Stats and Trends

• This season McCaffrey has rushed for a team-best 176 yards (58.7 ypg) on 52 carries.
• McCaffrey runs for 58.7 yards per game, less than Sunday’s prop total (72.5).
• Not once this season has McCaffrey run for more than 72.5 yards in a game.
• His average rushing yards over/under (71.5) is higher than his average total (58.7) this year.
• McCaffrey has topped his rushing yards over/under once in three games.
• In three games, he has not scored a rushing touchdown.
• McCaffrey has gathered 25 passes for 213 yards (71.0 ypg) and one touchdown.

Recent Performances vs. the Jaguars

49ers Home Splits (Last Season)

• At home, the 49ers put up 25.3 points per game and gave up 21.4. That’s more than they scored overall (22.9), but less than they gave up (25.6).
• At home, the 49ers accumulated 376.7 yards per game and conceded 294.8. That’s more than they gained overall (376.3), but less than they allowed (317.4).
• In home games, the 49ers accumulated 242.8 passing yards per game and gave up 183. That’s less than they gained (249.1) and allowed (192.8) overall.
• The 49ers’ average yards rushing at home (133.9) was higher than their overall average (127.2). And their average yards conceded at home (111.8) was lower than overall (124.6).
• The 49ers’ offensive third-down percentage in home games (46.7%) was higher than their overall average (42.6%). Their defensive third-down percentage at home (43%) was lower than overall (43.1%).