Reds vs. Cardinals Betting Lines, Odds, & Player Matchups September 17, 2025

Data Skrive
Data Skrive

The Cincinnati Reds (75-76) visit the St. Louis Cardinals (74-78) at 1:15 p.m. ET on Wednesday at Busch Stadium. The Reds are favored (-115) to break the 1-1 tie and take the series over the Cardinals (-105). Cincinnati has Brady Singer starting, and St. Louis counters with Andre Pallante.

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Money Line

Reds to win vs Cardinals -115

Bet $20, Payout $37.39

Reds vs. Cardinals betting lines

  • Favorite: Reds (-115)
  • Underdog: Cardinals (-105)
  • Over/under: 8.5

Reds betting info, hitting leaders, & pitching

Reds betting info

  • The Reds have a 33-32 record in games they were favored on the moneyline (winning 50.8% of those games).
  • Cincinnati has a 29-28 record (winning 50.9% of its games) when it has played as moneyline favorites of -115 or shorter.
  • The Reds have a 53.5% chance to win this contest based on the moneyline’s implied probability.
  • Cincinnati has played in 148 games with over/under set, and have combined with opponents to go over the total 57 times (57-84-7).
  • The Reds have a 76-72-0 record ATS this season (covering 51.4% of the time).

Reds hitting info

  • Elly De La Cruz paces the Reds in home runs (19), runs batted in (82) and has a team-best batting average of .264.
  • In MLB action, De La Cruz ranks 81st in homers and 32nd in RBI.
  • De La Cruz takes a two-game hitting streak into this game. During his last five outings he is batting .188 with a double and four walks.
  • TJ Friedl is hitting .259 with 20 doubles, two triples, 12 home runs and 76 walks.
  • Friedl ranks 164th in home runs among batters in MLB play and 176th in RBI.
  • Spencer Steer is hitting .237 with 20 doubles, two triples, 17 home runs and 45 walks.
  • Austin Hays is batting .266 with 15 doubles, five triples, 15 home runs and 29 walks.

Reds pitching rankings

  • The 8.6 strikeouts per nine innings compiled by the Reds pitching staff ranks 12th in MLB.
  • Cincinnati has the 15th-ranked team ERA among all MLB pitching staffs (4.00).
  • The Reds average MLB’s 11th-ranked WHIP (1.244).
  • Reds pitchers combine to give up the 20th-fewest home runs in baseball (182 total, 1.2 per game).
  • Cincinnati its 3-0 loss the last time out, the team struck out nine Cardinals batters while allowing eight hits.

Cardinals betting info, hitting leaders, & pitching

Cardinals betting info

  • This season, the Cardinals have been the underdog 84 times and won 40, or 47.6%, of those games.
  • St. Louis has a record of 34-42 in games where sportsbooks have it as underdogs of at least -105 on the moneyline.
  • The Cardinals have a 51.2% chance to win this game based on the implied probability of the moneyline.
  • Games involving St. Louis have gone over the total set by sportsbooks in 76 of 151 chances this season.
  • The Cardinals are 76-75-0 against the spread this season.

Cardinals hitting info

  • Alec Burleson leads St. Louis in batting average (.283) this season while adding 17 home runs and 65 RBI.
  • Burleson is 101st in home runs and 90th in RBI among all hitters in the big leagues.
  • Willson Contreras is batting .257 this season with a team-high 20 home runs and 80 RBI.
  • Contreras ranks 70th in home runs and 38th in RBI among all MLB batters this season.
  • Contreras has safely hit in three games in a row. During his last five outings he is hitting .353 with a double, two walks and two RBIs.
  • Brendan Donovan is batting .283 to lead St. Louis, while adding 10 homers and 47 runs batted in this season.
  • Donovan enters this game on a four-game hitting streak. In his last five games he is batting .292 with a double, a home run, a walk and two RBIs.
  • Lars Nootbaar has collected 114 hits this season and has an OBP of .322. He’s slugging .369 on the year.

Cardinals pitching rankings

  • The Cardinals have a 7.5 K/9 this season as a pitching staff, which ranks 29th in baseball.
  • St. Louis has the 21st-ranked ERA (4.29) in the majors this season.
  • The Cardinals have a combined WHIP of 1.320 as a pitching staff, which ranks 22nd in MLB.
  • The Cardinals have allowed the fourth-fewest home runs this season at just 155, or one per game.
  • St. Louis pitchers struck out nine Reds batters while allowing three hits in a 3-0 win last time out.
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Betting Guide

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How to Bet Odds

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If you are a golfer or have ever played on a bowling team, think of a point spread like a handicap. It is a way for two teams of differing abilities to play each other on equal footing.  The better team, and the favorite in the game, gives a certain amount …