The Clemson Tigers (3-4) and the Duke Blue Devils (4-3) play on Saturday, November 1, 2025 at Memorial Stadium (Clemson, SC) in a battle of ACC opponents.

The Blue Devils are underdogs, but by less than a touchdown (+3.5), versus the Tigers (with an over/under of 54.5 points).

Below you’ll find our betting preview for this this game between the Tigers and the Blue Devils, and uncover all of our predictions here, too!

Clemson vs. Duke betting lines

• Spread favorite: Tigers (-3.5)
• Moneyline: Tigers (-178), Blue Devils (+148)
• Total: 54.5 points
• TV Channel: ACC Network
• Live Stream: Fubo

Clemson vs. Duke betting info and stats

Clemson, in seven games with a spread so far this season, is 2-5-0 against the spread. Clemson has covered the spread twice when the favorite by at least 3.5 points (a 2-4 ATS record). Clemson has been the moneyline favorite in seven games this season, and it has put together a 3-4 record in those matchups. Duke has three wins against the spread so far this season (3-4-0). Duke has been listed as the underdog on the moneyline in two games so far this season, and it lost both games.

Clemson vs. Duke recent stats and trends

Clemson Tigers

• Clemson is 2-1 against the spread and 2-1 overall over its last three contests.
• Clemson and its opponents have hit the over in two of those games.
• The past three Clemson games averaged 3.7 fewer points (50.8) than this matchup’s over/under.

Duke Blue Devils

• Duke is 2-1 against the spread and 2-1 overall during its last three matchups.
• The final combined score of the last three Duke games exceeded the set total one time.
• The past three Duke games averaged 4.0 more points (58.5) than this matchup’s over/under.

Clemson vs. Duke key players

Clemson Tigers

• Cade Klubnik leads Clemson with 1,530 yards (255.0 ypg) on 133-of-202 passing with 11 touchdowns and five interceptions this season. He also has 104 rushing yards on 47 carries while scoring two touchdowns on the ground.
• Adam Randall has racked up 433 yards on 85 carries while finding paydirt four times as a runner. He’s also caught 24 passes for 182 yards (30.3 per game) and three touchdowns through the air.
• Bryant Wesco Jr.’s leads his squad with 537 yards as a receiver. He’s racked up that yardage on 31 catches (out of 45 targets) and scored six touchdowns.
• T.J. Moore has caught 26 passes for 407 yards (58.1 yards per game) and three touchdowns this year.
• Antonio Williams has a total of 225 receiving yards so far this year, hauling in 23 passes.
• Will Heldt has 3.0 sacks to pace the team, and also has 6.0 TFL and 25 tackles.
• Sammy Brown is the team’s top-tackler this year. He’s picked up 48 tackles, 4.0 TFL, and two sacks.
• Ricardo Jones leads the team with three interceptions, while also recording 21 tackles, 1.0 TFL, and three passes defended.

Duke Blue Devils

• Darian Mensah has thrown for 2,211 yards on 70.3% passing while recording 17 touchdown passes with two interceptions this season.
• Nate Sheppard has rushed for 497 yards on 71 carries so far this year while scoring four times on the ground. He’s also tacked on 18 catches, totaling 132 yards and one touchdown through the air.
• Anderson Castle has racked up 295 yards (on 53 carries) with six touchdowns.
• Cooper Barkate has registered 39 receptions this season and his team-high yardage total sits at 647 (92.4 yards per game). He’s been targeted 60 times and has four touchdowns.
• Sean Brown has 30 receptions (on 41 targets) for a total of 439 yards (62.7 yards per game) and one touchdown this year.
• Sahmir Hagans’ 25 grabs (on 32 targets) have netted him 317 yards (45.3 ypg) and five touchdowns.
• Vincent Anthony Jr. leads the team with 6.5 sacks, and also has 8.0 TFL and 22 tackles.
• Caleb Weaver, Duke’s top tackler, has 51 tackles, 2.0 TFL, 0.5 sacks, and one interception this year.
• Moussa Kane has a team-high two interceptions to go along with 10 tackles, 1.0 TFL, and two passes defended.