The Clemson Tigers (3-5) meet a fellow ACC opponent when they host the Florida State Seminoles (4-4) on Saturday, November 8, 2025 at Memorial Stadium (Clemson, SC).

The Tigers are slight favorites (-1.5) in their game versus the Seminoles, with the over/under being 56.5 points. (In terms of the moneyline, the Tigers are -121 and the Seminoles are +102.)

Keep reading to check out our preview for this this matchup between the Tigers and the Seminoles, and find all of our betting picks here, too!

Clemson vs. Florida State betting lines

• Spread favorite: Tigers (-1.5)
• Moneyline: Tigers (-121), Seminoles (+102)
• Total: 56.5 points
• TV Channel: ACC Network
• Live Stream: Fubo

Clemson vs. Florida State betting info and stats

Clemson has a pair of wins against the spread so far this season (2-6-0). Clemson has covered the spread two times this season when listed as a favorite by at least 1.5 points. Clemson has put together a 3-5 record in the eight games this season it has been moneyline favorites. Florida State has three wins against the spread so far this season (3-4-0). When Florida State is an underdog by 1.5 points or more, it has covered the spread one time (1-1 ATS). This is the third game this year Florida State is an underdog on the moneyline, after split the two games.

Clemson vs. Florida State recent stats and trends

Clemson Tigers

• Clemson has covered the spread once in its past three matchups while putting up a 1-2 record straight-up in those games.
• The final combined score of the past three Clemson games has exceeded the set total two times.
• The last three Clemson games averaged 53.2 total points, 3.3 fewer points than this matchup’s point total.

Florida State Seminoles

• Florida State is 1-2 against the spread and 1-2 overall in its last three matchups.
• Florida State and its opponents have hit the over in one of those games.
• The past three Florida State games averaged 2.0 fewer points (54.5) than this matchup’s point total.

Clemson vs. Florida State key players

Clemson Tigers

• Cade Klubnik has been a dual threat for Clemson so far this season. He has 1,915 passing yards, completing 67.2% of his passes and throwing 13 touchdown passes and five interceptions this season. He’s rushed for 116 yards (16.6 ypg) on 51 carries with two rushing touchdowns.
• Adam Randall has 522 rushing yards on 101 carries with six touchdowns. He’s also tacked on 25 catches for 192 yards (27.4 per game) and three touchdowns via the passing game.
• Bryant Wesco Jr. has hauled in 31 receptions for 537 yards (76.7 yards per game) to lead the team so far this season. He’s found the end zone six times as a receiver.
• T.J. Moore has grabbed 28 passes while averaging 62.4 yards per game and scoring four touchdowns.
• Antonio Williams has a total of 367 receiving yards so far this year, hauling in 33 passes and scoring one touchdown.
• Jahiem Lawson has 3.5 sacks to pace the team, and also has 5.0 TFL and 17 tackles.
• Sammy Brown, Clemson’s leading tackler, has 52 tackles, 4.0 TFL, and two sacks this year.
• Ricardo Jones has picked off a team-high three passes. He also has 23 tackles, 1.0 TFL, and three passes defended to his name.

Florida State Seminoles

• Thomas Castellanos has been a dual threat for Florida State this season. He has 1,878 passing yards (234.8 per game) while completing 61.5% of his passes. He’s tossed 10 touchdown passes and five interceptions this season. On the ground, he’s compiled 328 yards (41.0 ypg) on 89 carries with six rushing touchdowns.
• Gavin Sawchuk is his team’s leading rusher with 93 carries for 432 yards, or 54.0 per game. He’s found paydirt eight times on the ground, as well.
• Duce Robinson’s 689 receiving yards (86.1 yards per game) are a team high. He has 34 receptions on 56 targets with four touchdowns.
• Micahi Danzy has caught 21 passes and compiled 503 receiving yards (62.9 per game) with two touchdowns.
• Lawayne McCoy has racked up 186 reciving yards (31.0 ypg) and one touchdown this season.
• Mandrell Desir has collected 3.0 sacks to pace the team, while also picking up 4.0 TFL and 13 tackles.
• Earl Little II has 52 tackles, 1.0 TFL, and four interceptions, and leads the team in both tackles and interceptions.