ACC foes meet when the No. 11 Clemson Tigers (6-1) and the Louisville Cardinals (5-3) play on Saturday, November 2, 2024 at Memorial Stadium (Clemson, SC).

The Tigers are double-digit favorites (currently -10.5) in their game versus the Cardinals, with the over/under at 61.5 points. (In terms of the moneyline, the Tigers are -426 and the Cardinals are +321.)

Read on for our betting preview for this this matchup between the Tigers and the Cardinals, and discover all of our betting picks here, too!

Clemson vs. Louisville betting lines

• Spread favorite: Tigers (-10.5)
• Moneyline: Tigers (-426), Cardinals (+321)
• Total: 61.5 points
• TV Channel: ESPN
• Live Stream: Fubo (Watch for free)

Clemson vs. Louisville betting info and stats

Clemson has four wins against the spread through seven opportunities this season (4-3-0). Clemson is 4-2 ATS this season when the favorite by 10.5 points or more. Clemson has won six of its six games played when favored on the moneyline this season. Louisville has a pair of wins against the spread this season (2-5-0). Louisville has been the underdog on the moneyline in two games so far this season, and it lost both games.

Clemson vs. Louisville recent stats and trends

Clemson Tigers

• Clemson is 1-2 against the spread over its past three games, and has a 3-0 straight-up record in those contests.
• The final combined score of the last three Clemson games exceeded the set total once.
• Clemson’s past three outings have ended with an average of 56 points scored. That’s 5.5 fewer points than this contest’s over/under.

Louisville Cardinals

• Louisville is winless against the spread over its last three games, and has a 3-0 straight-up record in those contest.
• The final combined score of the past three Louisville games has gone over the set total twice.
• Louisville’s last three outings have ended with an average of 56.5 points scored. That’s five fewer points than this contest’s over/under.

Clemson vs. Louisville key players

Clemson Tigers

• Cade Klubnik has been a dual threat for Clemson so far this season. He has 1,836 passing yards, completing 66.7% of his passes and recording 20 touchdown passes and three interceptions this season. He’s rushed for 227 yards (32.4 ypg) on 41 carries with four rushing touchdowns.
• Phil Mafah has 692 rushing yards on 106 carries with six touchdowns.
• Antonio Williams has hauled in 28 receptions for 393 yards (56.1 yards per game) to lead the team so far this season. He’s found the end zone five times as a receiver.
• Jake Briningstool has caught 29 passes for 327 yards (46.7 yards per game) and four touchdowns this year.
• T.J. Moore has a total of 268 receiving yards so far this year, hauling in 16 passes and scoring three touchdowns.
• T.J. Parker paces the team with five sacks, and also has five TFL and 21 tackles.
• Wade Woodaz is the team’s tackle leader this year. He’s racked up 36 tackles, three TFL, two sacks, and one interception.
• Avieon Terrell has picked off a team-leading two passes. He also has 24 tackles, two TFL, one sack, and four passes defended to his name.

Louisville Cardinals

• Tyler Shough has 2,348 passing yards, or 293.5 per game, so far this season. He has completed 64.3% of his passes and has recorded 20 touchdowns with five interceptions.
• Isaac Brown has run for 649 yards on 86 carries so far this year while scoring six times on the ground. He’s also added 23 catches, totaling 132 yards and one touchdown in the passing game.
• Duke Watson has rushed for 222 yards on 27 carries with two touchdowns.
• Ja’Corey Brooks leads his team with 799 receiving yards on 44 catches with eight touchdowns.
• Chris Bell has put up a 345-yard season so far with two touchdowns. He’s caught 20 passes on 35 targets.
• Ahmari Huggins-Bruce has racked up 226 reciving yards (28.3 ypg) this season.
• Tramel Logan leads the team with three sacks, and also has two TFL and seven tackles.
• TJ Quinn is the team’s top-tackler this year. He’s collected 33 tackles, one TFL, and one sack.
• T.J. Capers has picked off a team-leading one pass. He also has one pass defended to his name.