The Clemson Tigers (3-3) and the SMU Mustangs (4-2) play on Saturday, October 18, 2025 at Memorial Stadium (Clemson, SC) in a battle of ACC foes.

The Tigers are the favorites (-3.5) in their matchup against the Mustangs, with the over/under at 50.5 points. (In terms of the moneyline, the Tigers are -169 and the Mustangs are +143.)

Keep reading for our betting preview for this this matchup between the Tigers and the Mustangs, and uncover all of our expert predictions here, too!

Clemson vs. SMU betting lines

• Spread favorite: Tigers (-3.5)
• Moneyline: Tigers (-169), Mustangs (+143)
• Total: 50.5 points
• TV Channel: ACC Network
• Live Stream: Fubo

Clemson vs. SMU betting info and stats

Clemson has won two games against the spread this season (2-4-0). Clemson has covered the spread in two games when favored by at least 3.5 points (a 2-3 ATS record). Clemson has won three of its six games played when favored on the moneyline this season. SMU has won once against the spread this season (1-4-0). When SMU is an underdog of 3.5 points or more, it has not yet covered the spread. SMU has played a game as an underdog on the moneyline one time so far this season, and failed to pick up the victory.

Clemson vs. SMU recent stats and trends

Clemson Tigers

• Clemson has covered the spread twice in its past three contests while putting up a 2-1 record straight-up in those games.
• The final combined score of the past three Clemson games has gone over the set total twice.
• The last three Clemson games averaged 52.2 total points, 1.7 more points than this matchup’s point total.

SMU Mustangs

• SMU is 1-2 against the spread and 2-1 overall during its last three contests.
• The final combined score of each of the last three SMU games did not go over the set point total.
• The past three SMU games averaged 8.3 more points (58.8) than this matchup’s point total.

Clemson vs. SMU key players

Clemson Tigers

• Cade Klubnik has been a dual threat for Clemson so far this season. He has 1,530 passing yards, completing 65.8% of his passes and tossing 11 touchdown passes and five interceptions this season. He’s rushed for 104 yards (17.3 ypg) on 47 carries with two rushing touchdowns.
• The team’s top rusher, Adam Randall, has carried the ball 75 times for 404 yards (67.3 per game), scoring four times. He’s also caught 19 passes for 163 yards and three touchdowns.
• Bryant Wesco Jr.’s leads his squad with 537 yards as a receiver. He’s racked up that yardage on 31 receptions (out of 44 targets) and scored six touchdowns.
• T.J. Moore has put together a 283-yard season so far with one touchdown, hauling in 21 passes on 40 targets.
• Antonio Williams has been the target of 25 passes and racked up 17 grabs for 171 yards, an average of 42.8 yards per contest.
• Jahiem Lawson has 2.5 sacks to lead the team, and also has 3.0 TFL and 14 tackles.
• Sammy Brown, Clemson’s leading tackler, has 39 tackles, 3.0 TFL, and two sacks this year.
• Ricardo Jones has a team-high two interceptions to go along with 19 tackles, 1.0 TFL, and two passes defended.

SMU Mustangs

• Kevin Jennings has compiled 1,658 yards (276.3 ypg) while completing 71.7% of his passes and collecting 15 touchdown passes with six interceptions this season.
• Tomarion Harden has carried the ball 85 times for 414 yards, with five touchdowns.
• Chris Johnson Jr. has compiled 226 yards on 28 carries with two touchdowns, while also catching eight passes for 122 yards and one score.
• Romello Brinson’s 484 receiving yards (80.7 yards per game) lead the team. He has 32 receptions on 39 targets with three touchdowns.
• Jalen Cooper has caught 15 passes and compiled 271 receiving yards (54.2 per game) with two touchdowns.
• Jordan Hudson has racked up 203 reciving yards (50.8 ypg) and two touchdowns this season.
• Cam Robertson leads the team with 4.5 sacks, and also has 5.0 TFL and 24 tackles.
• Ahmaad Moses has 37 tackles, 3.0 TFL, one sack, and two interceptions, and leads the team in both tackles and interceptions.