Guardians vs. White Sox Betting Lines, Odds, & Player Matchups September 12, 2025

Data Skrive
Data Skrive

The Cleveland Guardians (75-71) host the Chicago White Sox (57-90) on Friday at 7:10 p.m. ET. The Guardians are favored (-173) against the underdog White Sox (+144). Cleveland’s Tanner Bibee and Chicago’s Martin Perez pitch first for their squads in this matchup.

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Moneyline

Guardians to win vs White Sox -173

Bet $20, Payout $31.56

Guardians vs. White Sox betting lines

  • Favorite: Guardians (-173)
  • Underdog: White Sox (+144)
  • Over/under: 7.5

Guardians betting info, hitting leaders, & pitching

Guardians betting info

  • The Guardians have won 37 of the 61 games they were listed as the moneyline favorite this season (60.7%).
  • When it has played as moneyline favorites with odds of -173 or shorter, Cleveland has gone 6-1 (85.7%).
  • The implied moneyline probablility for this matchup gives the Guardians a 63.4% chance to win.
  • Cleveland has played in 144 games with a set over/under, and have combined with its opponents to go over the total 62 times (62-75-7).
  • The Guardians have put together a 74-70-0 record against the spread this season (covering 51.4% of the time).

Guardians hitting info

  • Jose Ramirez has a team-best batting average of .285, while leading the Guardians in home runs (28) and runs batted in (77).
  • Among all hitters in MLB, Ramirez’s home run total ranks 21st and his RBI tally ranks 42nd.
  • Steven Kwan has 26 doubles, a triple, 10 home runs and 50 walks while hitting .276.
  • Kwan ranks 188th in homers and 167th in RBI among hitters in MLB.
  • Kwan has safely hit in two straight games. In his last five games he is hitting .300 with a double, three walks and an RBI.
  • Kyle Manzardo is hitting .240 with 15 doubles, two triples, 26 home runs and 46 walks.
  • Manzardo brings a four-game hitting streak into this game. During his last five outings he is batting .375 with a double, a home run, three walks and four RBIs.
  • Angel Martinez has 21 doubles, a triple, 10 home runs and 18 walks while batting .225.

Guardians pitching rankings

  • The pitching staff for the Guardians has a collective 8.4 K/9, which ranks 16th in the majors.
  • Cleveland’s 3.86 team ERA ranks ninth among all MLB pitching staffs.
  • Pitchers for the Guardians combine for the 18th-ranked WHIP in baseball (1.303).
  • Guardians pitchers combine to allow the 10th-fewest home runs in baseball (156 total, 1.1 per game).
  • Cleveland defeated the Royals 3-2 in its last game with 11 strikeouts while allowing five hits.

White Sox betting info, hitting leaders, & pitching

White Sox betting info

  • The White Sox have won 56, or 38.6%, of the 145 games they’ve played as underdogs this season.
  • Chicago has a record of 25-53, a 32.1% win rate, when it’s set as an underdog of +144 or more by sportsbooks this season.
  • The bookmakers’ moneyline implies a 41% chance of a victory for the White Sox.
  • Chicago’s games have gone over the total in 68 of its 147 chances.
  • The White Sox are 87-60-0 against the spread in their 147 chances this season.

White Sox hitting info

  • Miguel Vargas has been key for Chicago with 105 hits, an OBP of .316 plus a slugging percentage of .401.
  • Vargas’ home run total ranks 140th in the majors, and he is 140th in RBI.
  • Andrew Benintendi has 100 hits and an OBP of .311 to go with a slugging percentage of .438 this season.
  • Benintendi ranks 76th among batters in MLB in homers, and 104th in RBI.
  • Benintendi has safely hit in five games in a row. In his last five games he is batting .333 with a double, two home runs, two walks and six RBIs.
  • Lenyn Sosa leads Chicago in batting average (.265), home runs (20) and runs batted in (67) this season.
  • Sosa heads into this game on a three-game hitting streak. In his last five games he is hitting .263 with a double, a home run, a walk and five RBIs.
  • Chase Meidroth is batting .269 with an OBP of .348 and a slugging percentage of .338 this season.
  • Meidroth takes a seven-game hitting streak into this game. During his last 10 games he is batting .400 with a double, a home run, five walks and three RBIs.

White Sox pitching rankings

  • The White Sox strike out eight batters per nine innings as a pitching staff, 22nd in MLB.
  • Chicago has the 20th-ranked ERA (4.23) in the majors this season.
  • White Sox pitchers have a 1.367 WHIP this season, fifth-worst in the majors.
  • The White Sox have given up the 14th-fewest long balls so far this season with 166 home runs allowed.
  • Chicago pitchers struck out six Rays batters while allowing seven hits in a 5-1 win last time out.
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