Tigers vs. Guardians Betting Lines, Odds, & Player Matchups May 21, 2026

Data Skrive

The Detroit Tigers (20-29) and the Cleveland Guardians (28-22) take the field on Thursday at Comerica Park, beginning at 1:10 p.m. ET. The Tigers are moneyline favorites (-116), while the Guardians are -103 underdogs, despite being favored against the spread (1.5) with +161 odds. Casey Mize takes the mound first for Detroit, and Joey Cantillo is Cleveland’s choice to start.

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Betting Odds

Tigers to win vs Guardians -116

Bet $20, Payout $37.24

Tigers vs. Guardians betting lines

  • Favorite: Tigers (-116)
  • Underdog: Guardians (-103)
  • Over/under: 7.5

Tigers betting info, hitting leaders, & pitching

Tigers betting info

  • The Tigers are 13-14 in games they were listed as the moneyline favorite (winning 48.1% of those games).
  • When playing as moneyline favorites with odds of -116 or shorter, Detroit has a 13-11 record (winning 54.2% of its games).
  • The implied moneyline probablility in this matchup gives the Tigers a 53.7% chance to win.
  • Detroit has played in 49 games with a set over/under, and have combined with its opponents to go over the total 22 times (22-25-2).
  • The Tigers have covered 49% of their games this season, going 24-25-0 ATS.

Tigers hitting info

  • Kevin McGonigle is batting .288 with 12 doubles, two triples, two home runs and 28 walks.
  • In MLB, McGonigle ranks 228th in home runs and 168th in RBI.
  • McGonigle has hit safely in four games in a row. In his last five games he is hitting .250 with two walks.
  • Riley Greene is hitting .335 to lead his team.
  • Greene ranks 130th in homers and 68th in RBI this season.
  • Greene takes a two-game hitting streak into this matchup. During his last five outings he is hitting .375 with two doubles, two walks and two RBIs.
  • Dillon Dingler paces the Tigers with eight home runs and 28 runs batted in.
  • Matt Vierling is hitting .212 with nine doubles, four home runs and 13 walks.
  • Vierling brings a two-game hitting streak into this matchup. During his last five outings he is batting .278 with two home runs, two walks and two RBIs.

Tigers pitching rankings

  • The Tigers pitching staff ranks 18th in the majors with a collective 8.3 strikeouts per nine innings.
  • Detroit has the 13th-ranked team ERA across all MLB pitching staffs (4.05).
  • The Tigers have the 16th-ranked WHIP in the majors (1.300).
  • The Tigers allow the sixth-fewest home runs in baseball (43 total, 0.9 per game).
  • Detroit lost to the Guardians 4-3 in its last game with four strikeouts while allowing four hits.

Guardians betting info, hitting leaders, & pitching

Guardians betting info

  • This season, the Guardians have won 12 out of the 22 games, or 54.5%, in which they’ve been the underdog.
  • Cleveland has a record of 12-9 in games where bookmakers have it as underdogs of at least -103 on the moneyline.
  • Oddsmakers have implied with the moneyline set for this matchup that the Guardians have a 50.7% chance to win.
  • So far this season, Cleveland and its opponents have hit the over in 26 of its 50 games with a total.
  • The Guardians have an ATS record of 28-22-0 in 50 games with a spread this season.

Guardians hitting info

  • Jose Ramirez has been key for Cleveland with eight home runs, 22 RBI and a batting average of .236 this season.
  • Ramirez’s home run total ranks 40th in the big leagues, and he is 85th in RBI.
  • Chase DeLauter leads Cleveland in runs batted in with 30 while batting .268 with seven homers.
  • DeLauter ranks 49th in homers and 26th in RBI among all hitters in the major leagues.
  • Brayan Rocchio is batting .282 to lead Cleveland, while adding four homers and 27 runs batted in this season.
  • Angel Martinez’s nine home runs are most among Cleveland batters. He’s driven in 25 runs this season while slugging .497.

Guardians pitching rankings

  • The Guardians strike out 9.4 batters per nine innings as a pitching staff, fourth-best in MLB.
  • Cleveland has pitched to a 3.79 ERA this season, which ranks ninth in baseball.
  • The Guardians have a combined WHIP of 1.273 as a pitching staff, which ranks 13th in MLB.
  • With 58 homers allowed, the Guardians rank 23rd in the league at preventing long balls.
  • Cleveland earned a 4-3 win in its most recent game, striking out 13 Tigers batters while allowing seven hits.
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