Duke vs. Louisville betting: College basketball preview for Jan. 26

Data Skrive
Data Skrive

The No. 4 Duke Blue Devils (18-1, 7-0 ACC) are 8.5-point favorites as they attempt to extend a seven-game win streak when they host the No. 20 Louisville Cardinals (14-5, 4-3 ACC) on Monday, January 26, 2026 at Cameron Indoor Stadium. The contest airs at 7 p.m. ET on ESPN. The over/under for the matchup is 157.5.

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Duke Cover -8.5 vs Louisville -110

Bet $20, Payout $38.18

Duke vs. Louisville betting lines

  • Duke moneyline odds to win: -455
  • Louisville moneyline odds to win: +346
  • Spread: Duke (-8.5)
  • Total: 157.5

Duke statistics, trends and more

As the home team

  • Duke owns a worse record against the spread when playing at home (3-6-0) than it does on the road (5-1-0).
  • In home games, the Blue Devils exceed the total 33.3% of the time (three of nine games). They hit the over in the same percentage of away games (two of six contests).
  • In seven home games as a moneyline favorite, Duke has seven wins (1.000). It sports an identical winning percentage (5-0 record) as a moneyline favorite in road games.

Recent trends

  • The Blue Devils’ offense has been less productive over their last 10 games, scoring 82.7 points a contest compared to the 85.7 they’ve averaged this year.
  • The past 10 games have seen Duke allow 5.1 more points per game (70.4) than its season-long average (65.3).
  • The Blue Devils are trending down from beyond the arc during their last 10 outings, making 8.4 threes per game and shooting 32.8% from long range in comparison to their season-long averages of 9.2 makes and 34.4% from distance in the 2025-26 season.

Duke betting records this season

  • ATS Record: 10-9-0 (Home: 3-6-0; Away: 5-1-0)
  • ATS Record When Favored by 8.5+: 8-9-0 (As Favorite: 10-9-0; As Underdog: 0-0-0)
  • O-U-P: 6-13-0 (Home: 3-6-0; Away: 2-4-0)
  • Record When Moneyline Favorite: 15-1 (Home: 7-0; Away: 5-0)
  • Record When Moneyline Underdog: 0-0 (Home: 0-0; Away: 0-0)
Field Goal % Opp. Field Goal % Rebounds Opp. Rebounds Assists Turnovers
49.8 (22nd in nation) 39.3 (18th) 37.4 (19th) 27.6 (24th) 17.3 (39th) 11.2 (169th)

Need to know more about sports betting before you put down a wager on Duke vs. Louisville? Here’s everything you need to know about how to bet.

Louisville statistics, trends and more

As the away team

  • Louisville has been better against the spread at home (7-5-0) than away (2-3-0) this season.
  • In 2025-26 a lower percentage of the Cardinals’ games have finished above the over/under at home (33.3%, four of 12) than on the road (40%, two of five).
  • The Cardinals’ winning percentage at home when moneyline underdogs is .000, both at home (0-1) and on the road (0-1).

Recent trends

  • The Cardinals are posting 82.4 points per contest in their past 10 games, which is 5.4 fewer points than their average for the season (87.8).
  • Louisville is giving up 71.5 points per game in its past 10 games, compared to its season average of 69.6 points allowed.
  • The Cardinals are making 0.6 fewer threes per contest in their previous 10 games (11.3) compared to their season average (11.9), and they are putting up a worse three-point percentage over their past 10 contests (34.7%) compared to their season mark (35.3%).

Louisville betting records this season

  • ATS Record: 11-8-0 (Home: 7-5-0; Away: 2-3-0)
  • O-U-P: 7-12-0 (Home: 4-8-0; Away: 2-3-0)
  • Record When Moneyline Favorite: 13-3 (Home: 9-1; Away: 2-2)
  • Record When Moneyline Underdog: 0-2 (Home: 0-1; Away: 0-1)
Field Goal % Opp. Field Goal % Rebounds Opp. Rebounds Assists Turnovers
46.9 (97th in nation) 39.3 (18th) 39 (seventh) 30.3 (136th) 17.8 (22nd) 11.3 (175th)
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