ACC foes meet when the Duke Blue Devils (5-5) and the North Carolina Tar Heels (4-6) play on Saturday, November 22, 2025 at Kenan Stadium.

The Blue Devils are favored, but by less than a touchdown (-6.5), versus the Tar Heels. The over/under for this matchup is 51.5 points.

Keep reading for our preview for this this matchup between the Blue Devils and the Tar Heels, and uncover all of our expert picks here, too!

Duke vs. North Carolina betting lines

• Spread favorite: Blue Devils (-6.5)
• Moneyline: Blue Devils (-255), Tar Heels (+206)
• Total: 51.5 points
• TV Channel: ACC Network
• Live Stream: Fubo

Duke vs. North Carolina betting info and stats

Duke is 4-6-0 against the spread through 10 opportunities so far this season. Duke is winless ATS (0-2) when the favorite by at least 6.5 points. In the seven games favored on the moneyline, Duke has recorded a 4-3 record. North Carolina has a 5-5-0 record against the spread this season. In the four games North Carolina has been the underdog by at least 6.5 points, it covered the spread two times. North Carolina has a 1-6 record this year in games it hs been an underdog on the moneyline.

Duke vs. North Carolina recent stats and trends

Duke Blue Devils

• Duke has covered the spread once in its past three matchups while putting up a 1-2 record straight-up in those games.
• The final combined score of the last three Duke games has exceeded the set total two times.
• Duke’s past three games have ended with an average of 59.5 points scored. That’s 8.0 more points than this contest’s over/under.

North Carolina Tar Heels

• North Carolina has covered the spread once in its last three contests while putting together a 1-2 record straight-up in those games.
• North Carolina and its opponents have hit the over in one of those games.
• The past three North Carolina games averaged 9.5 fewer points (42.0) than this matchup’s point total.

Duke vs. North Carolina key players

Duke Blue Devils

• Darian Mensah has racked up 3,007 yards (300.7 ypg) on 242-of-356 passing with 25 touchdowns compared to four interceptions this season.
• Nate Sheppard has carried the ball 112 times for a team-high 700 yards on the ground and has found the end zone seven times as a runner. He’s also tacked on 24 catches for 157 yards (15.7 per game) and one touchdown via the passing game.
• Anderson Castle has carried the ball 69 times for 365 yards (36.5 per game) and six touchdowns.
• Cooper Barkate’s 869 yards as a receiver lead the team. He’s been targeted 82 times and has totaled 53 receptions and six touchdowns.
• Sean Brown has caught 44 passes for 594 yards (59.4 yards per game) and three touchdowns this year.
• Sahmir Hagans’ 31 receptions have yielded 377 yards and five touchdowns.
• Vincent Anthony Jr. has 6.5 sacks to lead the team, and also has 9.0 TFL and 26 tackles.
• Caleb Weaver, Duke’s top tackler, has 70 tackles, 3.0 TFL, 1.5 sacks, and one interception this year.
• Chandler Rivers has a team-high two interceptions to go along with 39 tackles, 1.0 TFL, and six passes defended.

North Carolina Tar Heels

• Gio Lopez has thrown for 1,425 yards on 63.3% passing while tossing eight touchdown passes with five interceptions this season. He’s also rushed for 121 yards with two scores.
• Demon June’s team-high 452 rushing yards have come on 76 carries, with two touchdowns. He also leads the team with 150 receiving yards (21.4 per game) on 14 catches with one touchdown.
• Benjamin Hall has racked up 236 yards (on 63 carries) with two touchdowns.
• Jordan Shipp has hauled in 498 receiving yards on 44 catches to pace his team so far this season while scoring four touchdowns as a receiver.
• Kobe Paysour has 25 receptions (on 45 targets) for a total of 325 yards (36.1 yards per game) and one touchdown this year.
• Melkart Abou-Jaoude paces the team with 10.0 sacks, and also has 9.0 TFL and 29 tackles.
• Khmori House, North Carolina’s leading tackler, has 59 tackles, 2.0 TFL, one sack, and one interception this year.
• Jaiden Patterson leads the team with one interception, while also recording 22 tackles, 1.0 TFL, and one pass defended.