The Duke Blue Devils (2-2) play a conference opponent when they visit the Syracuse Orange (3-1) on Saturday, September 27, 2025 at the JMA Wireless Dome in an ACC clash.
The Orange are underdogs, but by less than a touchdown (+4.5), against the Blue Devils (with an over/under of 59.5 points).
Keep reading for our betting primer for this this game between the Blue Devils and the Orange, and discover all of our betting picks here, too!
Odds to Cover
Bet $20, Payout $38.69
Duke -4.5 vs. Syracuse
Duke vs. Syracuse betting lines
- Spread favorite: Blue Devils (-4.5)
- Moneyline: Blue Devils (-188), Orange (+154)
- Total: 59.5 points
- TV Channel: ACC Network
- Live Stream: Fubo
Duke vs. Syracuse betting info and stats
- Duke has a single win against the spread so far this season (1-3-0). Duke is winless ATS (0-1) when the favorite by at least 4.5 points. Duke has won both games as the moneyline favorite this season. Syracuse has a pair of wins against the spread so far this season (2-1-1). When Syracuse is an underdog by 4.5 points or more, it has covered the spread once (1-1 ATS). This will be the third game this year Syracuse is an underdog on the moneyline, after split the two games.
Duke vs. Syracuse recent stats and trends
Duke Blue Devils
Syracuse Orange
Duke vs. Syracuse key players
Duke Blue Devils
- Darian Mensah has thrown for 1,305 yards (326.3 ypg) to lead Duke, completing 67.3% of his passes and recording 11 touchdown passes compared to two interceptions this season.
- Anderson Castle has carried the ball 22 times for a team-high 193 yards on the ground and has found the end zone three times as a runner. He’s also tacked on 10 catches for 63 yards (15.8 per game).
- Nate Sheppard has carried the ball 29 times for 188 yards (47.0 per game) while also racking up 63 yards through the air, scoring one time.
- Cooper Barkate’s 337 yards as a receiver lead the team. He’s been targeted 31 times and has totaled 17 receptions and one touchdown.
- Sean Brown has put up a 232-yard season so far, hauling in 16 passes on 24 targets.
- Sahmir Hagans has compiled 12 catches for 179 yards, an average of 44.8 yards per game. He’s scored four times as a receiver this season.
- Vincent Anthony Jr. leads the team with 5.0 sacks, and also has 5.0 TFL and 13 tackles.
- DaShawn Stone is the team’s top-tackler this year. He’s amassed 31 tackles and one interception.
- Moussa Kane has a team-high one interception to go along with one pass defended.
Syracuse Orange
- Steve Angeli has compiled 1,352 yards (338.0 ypg) while completing 62.8% of his passes and recording 10 touchdown passes with two interceptions this season.
- Yasin Willis has run for 233 yards on 52 carries so far this year while scoring four times on the ground.
- Will Nixon has run for 175 yards across 40 attempts, scoring two touchdowns. He’s chipped in with 11 catches for 99 yards.
- Darrell Gill Jr.’s 310 receiving yards (77.5 yards per game) are best on his team. He has 14 catches on 25 targets with three touchdowns.
- Dan Villari has racked up 240 receiving yards (60.0 yards per game) on 20 receptions.
- Johntay Cook II’s 30 targets have resulted in 18 grabs for 234 yards and one touchdown.
- Braheem Long Jr. has 2.0 sacks to pace the team, and also has 2.0 TFL, 15 tackles, and one interception.
- Darian Chestnut, Syracuse’s top tackler, has 21 tackles this year.
- Davien Kerr leads the team with one interception, while also recording eight tackles and one pass defended.
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BetDecider Team
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