The Duke Blue Devils (5-3) visit the UConn Huskies (6-3) at Pratt and Whitney Stadium at Rentschler Field on Saturday, November 8, 2025.

The Huskies are expected to lose (currently +7.5) against the Blue Devils (with an over/under of 63.5 points).

Below you can find our betting preview for this this game between the Blue Devils and the Huskies, and find all of our betting picks here, too!

Duke vs. UConn betting lines

• Spread favorite: Blue Devils (-7.5)
• Moneyline: Blue Devils (-312), Huskies (+251)
• Total: 63.5 points
• TV Channel: CBS Sports Network
• Live Stream: Fubo

Duke vs. UConn betting info and stats

Duke, through eight games with a spread so far this season, has gone 4-4-0 against the spread. Duke has yet to cover the spread when serving as the favorite by at least 7.5 points (a 0-1 ATS record). Duke has been named as moneyline favorites five times this season, and has put up a 4-1 record in those matchups. UConn has a 4-3-2 record against the spread this season. UConn has played a game as the underdog on the moneyline in one game so far this season, and failed to pick up the victory.

Duke vs. UConn recent stats and trends

Duke Blue Devils

• Duke is 2-1 against the spread and 2-1 overall over its last three matchups.
• Duke and its opponents have hit the over twice in those games.
• Duke’s last three outings have ended with an average of 56.8 points scored. That’s 6.7 fewer points than this contest’s over/under.

UConn Huskies

• UConn has covered the spread twice in its last three matchups while putting up a 2-1 record straight-up in those games.
• In two of those three games, the final combined score has gone over the set total.
• The past three UConn games averaged 7.0 fewer points (56.5) than this matchup’s point total.

Duke vs. UConn key players

Duke Blue Devils

• Darian Mensah has thrown for 2,572 yards (321.5 ypg) to lead Duke, completing 69.7% of his passes and tossing 21 touchdown passes compared to two interceptions this season.
• Nate Sheppard has carried the ball 84 times for a team-high 557 yards on the ground and has found the end zone five times as a runner. He’s also tacked on 20 catches for 143 yards (17.9 per game) and one touchdown in the pass game.
• Anderson Castle has carried the ball 58 times for 319 yards (39.9 per game) and six touchdowns.
• Cooper Barkate’s leads his squad with 774 yards as a receiver. He’s racked up that yardage on 45 catches (out of 69 targets) and scored five touchdowns.
• Sean Brown has hauled in 36 passes while averaging 64.9 yards per game and scoring three touchdowns.
• Sahmir Hagans’ 28 catches have turned into 319 yards and five touchdowns.
• Vincent Anthony Jr. has collected 6.5 sacks to lead the team, while also recording 8.0 TFL and 25 tackles.
• Duke’s top-tackler, Caleb Weaver, has 56 tackles, 2.0 TFL, 0.5 sacks, and one interception this year.
• Moussa Kane has a team-leading two interceptions to go along with 12 tackles, 2.0 TFL, one sack, and two passes defended.

UConn Huskies

• Joe Fagnano has thrown for 2,529 yards (281.0 yards per game) while completing 68.8% of his passes and tossing 22 touchdown passes this season. He’s also run for 91 yards with two touchdowns.
• Cam Edwards has run for 815 yards on 144 carries so far this year while scoring nine times on the ground.
• Jayden Brown has totaled 159 yards on 16 carries with one touchdown.
• Skyler Bell has collected 74 receptions this season and his team-high yardage total sits at 994 (110.4 yards per game). He’s been targeted 107 times and has 11 touchdowns.
• John Neider has put together a 347-yard season so far with one touchdown. He’s caught 21 passes on 28 targets.
• Javonte Vereen’s 17 catches (on 27 targets) have netted him 259 yards (32.4 ypg) and four touchdowns.
• Bryun Parham paces the team with 9.5 sacks. He’s also the team’s tackle leader, and has collected 9.0 TFL and 72 tackles.
• Cam Chadwick leads the team with four interceptions, while also recording 46 tackles, 1.0 TFL, one sack, and five passes defended.