Astros vs. Rays Betting Lines, Odds, & Player Matchups May 21, 2025

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Data Skrive

The Houston Astros (25-23) and the Tampa Bay Rays (22-26) play on Wednesday at 1:10 p.m. ET with the series tied 1-1. The Astros are favored (-143) to win the rubber match against the Rays (+121). Houston’s Hunter Brown starts against Tampa Bay’s Taj Bradley.

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Moneyline

Astros to win vs Rays -143

Bet $20, Payout $33.99

Astros vs. Rays betting lines

  • Favorite: Astros (-143)
  • Underdog: Rays (+121)
  • Over/under: 8.5

Astros betting info, hitting leaders, & pitching

Astros betting info

  • The Astros are 18-14 in games they were listed as the moneyline favorite (winning 56.2% of those games).
  • Houston has gone 6-5 when playing as moneyline favorites with odds of -143 or shorter (54.5% winning percentage).
  • The implied moneyline probablility in this matchup gives the Astros a 58.8% chance to win.
  • Houston has played in 48 games with set over/under, and have combined with opponents to go over the total 19 times (19-27-2).
  • The Astros have a 26-22-0 record against the spread this season (covering 54.2% of the time).

Astros hitting info

  • Isaac Paredes has put up a team-best eight home runs and 25 runs batted in.
  • In MLB action, Paredes ranks 41st in home runs and 58th in RBI.
  • Paredes takes a five-game hitting streak into this matchup. During his last five outings he is hitting .300 with two home runs, two walks and six RBIs.
  • Jeremy Pena has eight doubles, six home runs and 13 walks while batting .302.
  • Pena ranks 81st in homers and 74th in RBI this year.
  • Jake Meyers has racked up a team-high batting average of .307.
  • Meyers brings a five-game hitting streak into this game. In his last five games he is batting .412 with a double, a home run, three walks and two RBIs.
  • Jose Altuve is batting .242 with six doubles, four home runs and 14 walks.

Astros pitching rankings

  • The 9.4 strikeouts per nine innings put together by the Astros pitching staff ranks third in MLB.
  • Houston has the sixth-ranked team ERA among all MLB pitching staffs (3.38).
  • The Astros have the lowest WHIP in MLB (1.123).
  • The Astros surrender the seventh-fewest home runs in baseball (42 total, 0.9 per game).
  • Houston struck out five Rays batters while allowing six hits in a 3-2 loss in its last game.

Rays betting info, hitting leaders, & pitching

Rays betting info

  • The Rays have won 10, or 47.6%, of the 21 games they’ve played as underdogs this season.
  • This season, Tampa Bay has won seven of its 14 games, or 50%, when it’s the underdog by at least +121 on the moneyline.
  • Oddsmakers have implied with the moneyline set for this matchup that the Rays have a 45.2% chance to win.
  • Tampa Bay and its opponents have hit the over in 18 of its 48 games with a total this season.
  • The Rays have an ATS record of 20-28-0 in 48 games with a spread this season.

Rays hitting info

  • Yandy Diaz leads Tampa Bay in runs batted in with 24 while batting .250.
  • Diaz’s home run total ranks 81st in the big leagues, and he is 67th in RBI.
  • Diaz brings a five-game hitting streak into this game. During his last five outings he is hitting .350 with a double, a walk and four RBIs.
  • Jonathan Aranda is batting .310 to lead Tampa Bay, while adding six homers and 23 runs batted in this season.
  • Among all MLB hitters, Aranda is 81st in homers and 74th in RBI.
  • Junior Caminero’s eight home runs lead all Tampa Bay hitters, and he’s slugging .402.
  • Brandon Lowe leads Tampa Bay in runs batted in (24) this season. He’s batting .223 while slugging .367.
  • Lowe has safely hit in four straight games. During his last five outings he is batting .250 with a double and two walks.

Rays pitching rankings

  • The Rays strike out 7.7 batters per nine innings as a pitching staff, 25th in MLB.
  • Tampa Bay pitchers have a combined ERA of 3.88 ERA this year, which ranks 15th in MLB.
  • The Rays have a combined 1.221 WHIP as a pitching staff, 10th-lowest in MLB.
  • The Rays have allowed the fourth-most home runs this season with 67, or 1.4 per game.
  • Last time out, Tampa Bay defeated the Astros, 3-2, with 13 strikeouts and nine hits allowed.
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Betting Guide

How Money Line Works?

Moneyline betting is by far the easiest way to place a sports wager. There are no point spreads to parse, no garbage-time free throws to ruin your betting day, and no last-minute meaningless touchdowns to take you from a winner to a loser.

How to Bet Odds

When we, as sports fans, learned our multiplication tables, we aced the number 7. Seven, 14, 21, 28, 35, 42 were easy because we all watched football on the weekends. Multiplication by sevens, then add a three, a six after a missed PAT.

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If you are a golfer or have ever played on a bowling team, think of a point spread like a handicap. It is a way for two teams of differing abilities to play each other on equal footing.  The better team, and the favorite in the game, gives a certain amount …