The Houston Cougars (2-0) face a fellow Big 12 opponent when they host the Colorado Buffaloes (1-1) on Friday, September 12, 2025 at TDECU Stadium.
The Buffaloes are underdogs, but by less than a touchdown (+4), versus the Cougars (with an over/under of 45.5 points).
Keep reading to check out our betting primer for this this contest between the Cougars and the Buffaloes, and discover all of our predictions here, too!
Spread
Bet $20, Payout $38.18
Houston -4 vs. Colorado
Houston vs. Colorado betting lines
- Spread favorite: Cougars (-4)
- Moneyline: Cougars (-188), Buffaloes (+156)
- Total: 45.5 points
- TV Channel: ESPN
- Live Stream: Fubo
Houston vs. Colorado betting info and stats
- Houston has won two games against the spread so far this season (2-0-0). Houston has always covered the spread when favorites by at least 4 points (a 2-0 ATS record). Houston won both of the games it has played as the moneyline favorite this season. Colorado has a single win against the spread this season (1-1-0). Colorado has played a game as the underdog on the moneyline one time so far this season, and failed to pick up the victory.
Houston vs. Colorado key players
Houston Cougars
- Conner Weigman has 347 pass yards for Houston, completing 65.2% of his passes and collecting four touchdowns this season. He’s also chipped in on the ground with 62 rushing yards (31.0 ypg) on 16 carries with one rushing touchdown.
- Dean Connors has racked up 182 yards on 28 carries while finding the end zone two times as a runner.
- This season, Stacy Sneed has carried the ball 16 times for 66 yards (33.0 per game).
- Tanner Koziol has hauled in 13 receptions for 115 yards (57.5 yards per game) to lead the team so far this season. He’s found the end zone one time as a receiver.
- Stephon Johnson Jr. has put up a 74-yard season so far with one touchdown, reeling in one pass on five targets.
- Amare Thomas’ five catches have yielded 60 yards and one touchdown.
- Brandon Mack has collected 1.5 sacks to pace the team, while also picking up four tackles.
- Jalen Garner is the team’s tackle leader this year. He’s totaled six tackles.
- Marc Stampley II has picked off a team-high one pass. He also has one pass defended to his name.
Colorado Buffaloes
- Kaidon Salter has thrown for 261 yards on 68.2% passing while tossing one touchdown pass with zero interceptions this season. He’s also run for 68 yards with two scores.
- The team’s top rusher, Simeon Price, has carried the ball 14 times for 84 yards (42.0 per game).
- Micah Welch has racked up 78 yards (on 18 carries) with one touchdown.
- Sincere Brown has hauled in 120 receiving yards on four receptions to pace his squad so far this season while scoring one touchdown as a receiver.
- Dekalon Taylor has caught seven passes and compiled 87 receiving yards (43.5 per game) with two touchdowns.
- Joseph Williams’ five catches (on 10 targets) have netted him 65 yards (32.5 ypg).
- Quency Wiggins has 1.0 sack to lead the team, and also has 1.0 TFL.
- Reginald Hughes is the team’s tackle leader this year. He’s collected 14 tackles.
- RJ Johnson has picked off a team-leading one pass. He also has five tackles and one pass defended to his name.
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