Illinois vs. VCU betting: March Madness Second Round preview for March 21

Data Skrive

The No. 3 seed Illinois Fighting Illini (25-8) and the No. 11 seed VCU Rams (28-7) play in the NCAA Tournament second round, both looking to secure a place in the Sweet 16 of the South Region bracket when they meet on Saturday at Bon Secours Wellness Arena, tipping off at 7:50 p.m. ET. Illinois is a 10.5-point favorite in the Round of 32 contest, which airs on CBS. The matchup has an over/under set at 150.5 points.

Check out all the Latest NCAA Basketball Betting Previews!

Spread

Illinois Cover -10.5 vs VCU -121

Bet $20, Payout $36.53

Illinois vs. VCU betting lines

  • Illinois moneyline odds to win: -633
  • VCU moneyline odds to win: +441
  • Spread: Illinois (-10.5)
  • Total: 150.5

Illinois statistics, trends and more

Recent trends

  • In their last 10 games, the Fighting Illini have been scoring 85.9 points per contest, an average that’s slightly higher than the 85.0 they’ve scored over the course of the 2025-26 season.
  • Illinois has been less stingy on defense as of late, giving up 75.9 points per game over its last 10 contests compared to the 69.8 points per game its opponents average over the 2025-26 season.
  • The Fighting Illini’s last 10 contests have seen them make 10.6 three-pointers per game while shooting 32.4% from deep. Both numbers are down from their 2025-26 averages of 11.0 makes and 34.9%.

Illinois betting records this season

  • ATS Record: 19-14-0 (Home: 10-7-0; Away: 6-4-0)
  • ATS Record When Favored by 10.5+: 9-8-0 (As Favorite: 16-11-0; As Underdog: 3-3-0)
  • O-U-P: 15-18-0 (Home: 6-11-0; Away: 7-3-0)
  • Record When Moneyline Favorite: 22-5 (Home: 14-2; Away: 6-1)
  • Record When Moneyline Underdog: 3-3 (Home: 0-1; Away: 2-1)
Field Goal % Opp. Field Goal % Rebounds Opp. Rebounds Assists Turnovers
46.4 (101st in nation) 41.1 (34th) 37.8 (sixth) 27.9 (24th) 14.7 (118th) 8.4 (seventh)

Need to know more about sports betting before you put down a wager on Illinois vs. VCU? Here’s everything you need to know about how to bet.

VCU statistics, trends and more

Recent trends

  • The Rams are averaging 76.2 points per contest over their previous 10 games, which is 5.4 fewer points than their average for the season (81.6).
  • While VCU is surrendering 71.7 points per game in 2025-26, it has bettered that mark over its past 10 games, allowing 69.0 points per contest.
  • Over their previous 10 games, the Rams are making 9.2 three-pointers per game, 0.2 fewer threes than their season average (9.4). They have a better three-point percentage over their last 10 games (37.6%) compared to their season average (36.9%).

VCU betting records this season

  • ATS Record: 19-16-0 (Home: 7-10-0; Away: 6-4-0)
  • ATS Record When Underdog by 10.5+: 1-0-0 (As Favorite: 15-14-0; As Underdog: 4-2-0)
  • O-U-P: 16-19-0 (Home: 11-6-0; Away: 3-7-0)
  • Record When Moneyline Favorite: 26-3 (Home: 15-2; Away: 6-1)
  • Record When Moneyline Underdog: 2-4 (Home: 0-0; Away: 1-2)
Field Goal % Opp. Field Goal % Rebounds Opp. Rebounds Assists Turnovers
46.0 (127th in nation) 43.1 (104th) 33.6 (93rd) 30.4 (133rd) 14.0 (160th) 10.1 (95th)
Author Profile
BetDecider Team

The BetDecider team brings you the most current sports betting content, with expert insights and tips. Our aim is that you can make an informed betting decision, including best odds and exclusive sportsbook offers, to maximize your betting experience.

Ryan Knuppel

Knup Solutions [molongui_author_name]

About Ryan Knuppel

Ryan has been one of the leading sports business & iGaming professionals for over 15 years. He started as a freelance writer and now operates one of the top sports content agencies around, Knup Solutions. He has literally written 10,000 plus sports and betting related articles across the web.

 

Sports Network:

sports20.com, usawager.com, knupsports.com, baseballspotlight.com, basketballarticles.com, betdecider.com, njsportsbookreview.com, dunkelindex.com, sportspub.com, oddschoice.com

 

Betting Guide

How Money Line Works?

Moneyline betting is by far the easiest way to place a sports wager. There are no point spreads to parse, no garbage-time free throws to ruin your betting day, and no last-minute meaningless touchdowns to take you from a winner to a loser.

How to Bet Odds

When we, as sports fans, learned our multiplication tables, we aced the number 7. Seven, 14, 21, 28, 35, 42 were easy because we all watched football on the weekends. Multiplication by sevens, then add a three, a six after a missed PAT.

How to Bet on NFL Games

Baseball is America’s pastime, but football is America’s crazed passion, with its weekly schedule of games, millions of television viewers across the country and the world, and the billion-dollar stadiums that serve as Sunday cathedrals in 32 American cities.

What is the Spread?

If you are a golfer or have ever played on a bowling team, think of a point spread like a handicap. It is a way for two teams of differing abilities to play each other on equal footing.  The better team, and the favorite in the game, gives a certain amount …