Big Ten foes meet when the No. 3 Indiana Hoosiers (6-0) and the Michigan State Spartans (3-3) play on Saturday, October 18, 2025 at Memorial Stadium (Bloomington, IN).

The Spartans are expected to lose by at least two TDs (currently +27.5) versus the Hoosiers (with an over/under of 49.5 points).

Below you can find our betting preview for this this matchup between the Hoosiers and the Spartans, and uncover all of our expert predictions here, too!

Indiana vs. Michigan State betting lines

• Spread favorite: Hoosiers (-27.5)
• Moneyline: Hoosiers (-5882), Spartans (+1780)
• Total: 49.5 points

Indiana vs. Michigan State betting info and stats

Indiana has an against-the-spread record of 4-2-0 this season. In two games played when favored by at least 27.5 points, Indiana is undefeated ATS at 2-0. Indiana is 4-0 in the four games this season it has been favored on the moneyline. Michigan State, through six games with a set spread this season, has gone 2-4-0 against the spread. This is the third game this year Michigan State is an underdog on the moneyline, after losing the previous two such games.

Indiana vs. Michigan State recent stats and trends

Indiana Hoosiers

• Indiana is 2-1 against the spread over its last three games, and has a 3-0 straight-up record in those contests.
• Indiana and its opponents have combined to hit the over one time in those games.
• The last three Indiana games averaged 50.5 total points, 1.0 more point than this matchup’s point total.

Michigan State Spartans

• Michigan State is 2-1 against the spread and 3-0 overall during its past three matchups.
• Michigan State and its opponents have combined to hit the over two times in those games.
• The past three Michigan State games averaged 2.3 more points (51.8) than this matchup’s point total.

Indiana vs. Michigan State key players

Indiana Hoosiers

• Fernando Mendoza has compiled 1,423 yards (237.2 ypg) on 109-of-153 passing with 17 touchdowns compared to two interceptions this season. In addition, he’s added 133 rushing yards (22.2 ypg) on 36 carries while scoring two touchdowns on the ground.
• Roman Hemby has racked up 421 yards on 84 carries while finding the end zone two times as a runner. He’s also caught seven passes for 101 yards (20.2 per game).
• Kaelon Black has been handed the ball 62 times this year and racked up 375 yards (62.5 per game) with two touchdowns.
• Elijah Sarratt’s team-high 509 yards as a receiver have come on 38 catches (out of 54 targets) with seven touchdowns.
• Omar Cooper Jr. has caught 30 passes for 490 yards (81.7 yards per game) and six touchdowns this year.
• E.J. Williams has a total of 153 receiving yards so far this year, hauling in 14 throws and scoring two touchdowns.
• Isaiah Jones has collected 4.5 sacks to lead the team, while also picking up 8.0 TFL, 26 tackles, and one interception.
• Indiana’s top-tackler, Aiden Fisher, has 31 tackles, 4.0 TFL, and 2.5 sacks this year.
• Louis Moore has picked off a team-leading three passes. He also has 31 tackles, 2.0 TFL, and three passes defended to his name.

Michigan State Spartans

• Aidan Chiles has thrown for 1,019 yards (169.8 ypg) to lead Michigan State, completing 61.3% of his passes and collecting nine touchdown passes and three interceptions this season. He is also a playmaker on the ground, racking up 186 yards (31.0 ypg) on 58 carries with five touchdowns.
• The team’s top rusher, Makhi Frazier, has carried the ball 87 times for 383 yards (63.8 per game) with two touchdowns.
• Omari Kelly has hauled in 347 receiving yards on 24 receptions to pace his squad so far this season while scoring one touchdown as a receiver.
• Nick Marsh has put up a 340-yard season so far with four touchdowns. He’s caught 29 passes on 49 targets.
• Chrishon McCray has racked up 165 reciving yards (27.5 ypg) and one touchdown this season.
• Jalen Thompson has 2.0 sacks to lead the team, and also has 5.0 TFL and 15 tackles.
• Jordan Hall is the team’s top-tackler this year. He’s collected 43 tackles, 3.0 TFL, two sacks, and one interception.
• Armorion Smith has picked off a team-high one pass. He also has 20 tackles and one pass defended to his name.