The No. 2 Indiana Hoosiers (7-0) and the UCLA Bruins (3-4) play on Saturday, October 25, 2025 at Memorial Stadium (Bloomington, IN) in a clash of Big Ten opponents.

The Hoosiers are very heavy favorites (currently -26.5) in their matchup versus the Bruins, with the over/under being 53 points. (On the moneyline, the Hoosiers are -4167 and the Bruins are +1460.)

Below you’ll find our betting primer for this this matchup between the Hoosiers and the Bruins, and uncover all of our expert picks here, too!

Indiana vs. UCLA betting lines

• Spread favorite: Hoosiers (-26.5)
• Moneyline: Hoosiers (-4167), Bruins (+1460)
• Total: 53 points
• TV Channel: FOX 4K
• Live Stream: Fubo

Indiana vs. UCLA betting info and stats

Indiana has a 4-3-0 record against the spread this season. Indiana is 2-1 ATS when favored by at least 26.5 points. In five games as a moneyline favorite, Indiana is undefeated (5-0). UCLA, in seven games with a set spread this season, has gone 3-4-0 against the spread. UCLA has a 2-2 record this year in games it hs played as the moneyline underdog.

Indiana vs. UCLA recent stats and trends

Indiana Hoosiers

• Indiana is 1-2 against the spread in its last three games, and has a 3-0 straight-up record in those matchups.
• One time in those three games, the final combined score surpassed the set total.
• Indiana’s last three games have ended with an average of 49.8 points scored. That’s 3.2 fewer points than this contest’s over/under.

UCLA Bruins

• UCLA is 2-1 against the spread in its last three games and has a 3-0 straight-up record in those matchups.
• UCLA and its opponents have combined to hit the over in one of those games.
• The past three UCLA games averaged 2.2 fewer points (50.8) than this matchup’s point total.

Indiana vs. UCLA key players

Indiana Hoosiers

• Fernando Mendoza has 1,755 pass yards for Indiana, completing 73.5% of his passes and throwing 21 touchdowns and two interceptions this season. He’s also helped out on the ground with 151 rushing yards (21.6 ypg) on 41 carries with two rushing touchdowns.
• Kaelon Black has 439 rushing yards on 72 carries with three touchdowns.
• Roman Hemby has been handed the ball 90 times this year and racked up 432 yards (61.7 per game) with two touchdowns. He’s also helped out in the passing game with nine grabs for 120 yards
• Omar Cooper Jr.’s 605 yards as a receiver pace the team. He’s been targeted 46 times and has registered 38 catches and seven touchdowns.
• Elijah Sarratt has caught 42 passes for 579 yards (82.7 yards per game) and nine touchdowns this year.
• E.J. Williams has a total of 212 receiving yards so far this year, hauling in 19 throws and scoring three touchdowns.
• Isaiah Jones has 4.5 sacks to lead the team, and also has 9.0 TFL, 31 tackles, and one interception.
• Louis Moore has been all over the field, leading the team in both tackles and interceptions. He has 42 tackles, 2.0 TFL, and three interceptions so far.

UCLA Bruins

• Nico Iamaleava has been a dual threat for UCLA this season. He has 1,355 passing yards (193.6 per game) while completing 65.2% of his passes. He’s tossed 10 touchdown passes and five interceptions this season. On the ground, he’s compiled 360 yards (51.4 ypg) on 74 carries with four rushing touchdowns.
• Jaivian Thomas has piled up 54 carries and totaled 238 yards with one touchdown.
• Kwazi Gilmer leads his squad with 369 receiving yards on 30 receptions with two touchdowns.
• Titus Mokiao-Atimalala has put up a 240-yard season so far with three touchdowns. He’s caught 18 passes on 29 targets.
• Mikey Matthews has racked up 205 reciving yards (34.2 ypg) and one touchdown this season.
• Anthony Jones has 1.5 sacks to lead the team, and also has 2.0 TFL and 12 tackles.
• JonJon Vaughns is the team’s tackle leader this year. He’s amassed 57 tackles and 3.0 TFL.
• Scooter Jackson has picked off a team-high one pass. He also has 20 tackles, 1.0 TFL, and one pass defended to his name.