The No. 14 Iowa State Cyclones (3-0) visit the Arkansas State Red Wolves (1-1) at Centennial Bank Stadium on Saturday, September 13, 2025.

The Cyclones are very big favorites (currently -21.5) in their game against the Red Wolves, with the over/under at 55.5 points. (On the moneyline, the Cyclones are -1754 and the Red Wolves are +940.)

Keep reading to check out our preview for this this game between the Cyclones and the Red Wolves, and uncover all of our predictions here, too!

Iowa State vs. Arkansas State betting lines

• Spread favorite: Cyclones (-21.5)
• Moneyline: Cyclones (-1754), Red Wolves (+940)
• Total: 55.5 points
• TV Channel: ESPN2
• Live Stream: Fubo

Iowa State vs. Arkansas State betting info and stats

Iowa State, in three games with a spread so far this season, is 2-0-1 against the spread. Iowa State has won both games as the moneyline favorite this season. Arkansas State has a single win against the spread this season (1-1-0). When Arkansas State is an underdog of 21.5 points or more, it has not yet covered the spread. Arkansas State has played a game as an underdog on the moneyline one time this season, and failed to pick up the victory.

Iowa State vs. Arkansas State key players

Iowa State Cyclones

• Rocco Becht has 595 yards passing for Iowa State, completing 68% of his passes and collecting six touchdowns this season. He’s also contributed on the ground with 44 rushing yards (14.7 ypg) on 22 carries with one rushing touchdown.
• Carson Hansen has racked up 136 yards on 36 carries.
• Abu Sama III has collected 113 yards on 29 attempts, scoring one time.
• Brett Eskildsen’s 162 yards as a receiver lead the team. He’s been targeted 10 times and has totaled seven catches and one touchdown.
• Gabe Burkle has hauled in 10 receptions totaling 149 yards, finding the end zone one time as a receiver so far this campaign.
• Benjamin Brahmer has been the target of 15 passes and racked up 13 catches for 106 yards, an average of 35.3 yards per contest. He’s found the end zone three times through the air this season.
• Tamatoa McDonough paces the team with 2.0 sacks, and also has 2.0 TFL and eight tackles.
• Iowa State’s top-tackler, Marcus Neal, has 21 tackles, 3.0 TFL, and one sack this year.
• Jeremiah Cooper leads the team with one interception, while also putting up six tackles, 1.0 TFL, and one pass defended.

Arkansas State Red Wolves

• Jaylen Raynor has racked up 470 yards (235.0 per game) while completing 72.3% of his passes and recording four touchdown passes with two interceptions this season. He’s also rushed for 55 yards .
• The team’s top rusher, Devin Spencer, has carried the ball eight times for 73 yards (36.5 per game) with one touchdown.
• Kenyon Clay has run for 69 yards across 27 attempts, scoring one touchdown.
• Chauncy Cobb’s 135 receiving yards (67.5 yards per game) lead the team. He has nine receptions on 11 targets.
• Corey Rucker has put together a 79-yard season so far with one touchdown. He’s caught five passes on 14 targets.
• Hunter Summers’ three grabs (on four targets) have netted him 59 yards (29.5 ypg).
• Cody Sigler leads the team with 1.5 sacks, and also has 1.0 TFL and five tackles.
• Arkansas State’s top-tackler, Nigel Nelson, has 16 tackles this year.
• Avante Dickerson has picked off a team-high one pass. He also has six tackles and one pass defended to his name.