The Iowa State Cyclones (7-4) meet a fellow Big 12 foe when they visit the Oklahoma State Cowboys (1-10) on Saturday, November 29, 2025 at Boone Pickens Stadium.

The Cowboys are expected to lose by double digits (currently +13.5) against the Cyclones (with an over/under of 46.5 points).

Keep reading for our preview for this this matchup between the Cyclones and the Cowboys, and discover all of our betting picks here, too!

Iowa State vs. Oklahoma State betting lines

• Spread favorite: Cyclones (-13.5)
• Moneyline: Cyclones (-617), Cowboys (+448)
• Total: 46.5 points
• TV Channel: ESPN U
• Live Stream: Fubo

Iowa State vs. Oklahoma State betting info and stats

Iowa State is 5-5-1 against the spread through 11 opportunities so far this season. Iowa State has covered the spread once this season when favored by at least 13.5 points. Iowa State has won five of its eight games played as the moneyline favorite this season. Oklahoma State is 4-7-0 against the spread this season. In the nine games Oklahoma State has been the underdog by at least 13.5 points, it covered the spread four times (4-5). This will be the ninth game this year Oklahoma State is an underdog on the moneyline, and have lost every such contest.

Iowa State vs. Oklahoma State recent stats and trends

Iowa State Cyclones

• Iowa State is 2-1 against the spread in its past three games, and has a 2-1 straight-up record in those contests.
• In all of those games, the final combined score was under the set total.
• The past three Iowa State games averaged 7.3 more points (53.8) than this matchup’s point total.

Oklahoma State Cowboys

• Oklahoma State has covered the spread in each of its last three games, while going 2-1 overall.
• The final combined score of the past three Oklahoma State games went over the set total one time.
• The last three Oklahoma State games averaged 51.0 total points, 4.5 more points than this matchup’s over/under.

Iowa State vs. Oklahoma State key players

Iowa State Cyclones

• Rocco Becht has thrown for 2,471 yards (224.6 ypg) to lead Iowa State, completing 61.3% of his passes and recording 15 touchdown passes compared to nine interceptions this season.
• The team’s top rusher, Carson Hansen, has carried the ball 163 times for 841 yards (84.1 per game), scoring six times.
• This season, Abu Sama III has carried the ball 129 times for 645 yards (58.6 per game) and four touchdowns.
• Brett Eskildsen’s 507 yards as a receiver lead the team. He’s been targeted 49 times and has registered 29 catches and five touchdowns.
• Chase Sowell has hauled in 28 receptions totaling 446 yards, finding the end zone one time as a receiver so far this campaign.
• Benjamin Brahmer has hauled in 36 grabs for 422 yards, an average of 38.4 yards per game. He’s scored six times as a receiver this season.
• Will McLaughlin leads the team with 2.0 sacks, and also has 2.0 TFL and 12 tackles.
• Iowa State’s leading tackler, Marcus Neal, has 63 tackles, 8.0 TFL, one sack, and two interceptions this year.
• Jamison Patton leads the team with two interceptions, while also recording 43 tackles, 1.0 TFL, and two passes defended.

Oklahoma State Cowboys

• Zane Flores has put up 1,288 passing yards, or 161.0 per game, so far this season. He has completed 58.6% of his passes and has recorded three touchdowns with six interceptions. He’s also chipped in on the ground with 16.5 rushing yards per game while scoring as a runner two times.
• The team’s top rusher, Rodney Fields Jr., has carried the ball 124 times for 614 yards (68.2 per game) with one touchdown. He’s also caught 28 passes for 276 yards and one touchdown.
• Trent Howland has run for 206 yards across 49 attempts, scoring two touchdowns.
• Gavin Freeman has racked up 435 receiving yards on 46 receptions to pace his team so far this season while scoring four touchdowns as a receiver.
• Terrill Davis has collected 316 receiving yards (28.7 yards per game) on 24 receptions.
• Shamar Rigby has racked up 299 reciving yards (27.2 ypg) and one touchdown this season.
• Wendell Gregory has 4.0 sacks to lead the team, and also has 11.0 TFL and 27 tackles.
• So far Parker Robertson leads the team in both tackles and interceptions. He has racked up 70 tackles, 8.0 TFL, one sack, and two interceptions this season.