Jacoby Brissett and his Arizona Cardinals teamates will face the San Francisco 49ers at 4:05 p.m. ET on Sunday in Week 11 of the 2025 NFL season. In this piece, we’ll break down Brissett’s stats and trends to help you pick out the top bets among his props for this contest.

Jacoby Brissett Prop Lines

• Matchup: Arizona Cardinals vs. San Francisco 49ers
• Time: 4:05 p.m. ET
• Date: November 16, 2025
• Passing yards prop: Over 228.5 (-112)
• Rushing yards prop: Over 17.5 (-117)

Jacoby Brissett Stats and Trends

• Brissett has passed for 1,118 yards (186.3 per game), completing 60.9% of his throws, with eight TDs and one INT.
• Brissett throws for 186.3 yards per game. That’s 42.2 fewer yards than his over/under on Sunday.
• In four of six games this year, Brissett has exceeded 228.5 passing yards.
• His 186.3 passing yards per game are 37.2 lower than his average prop bet total of 223.5 yards.
• He has tossed a touchdown pass in four of six games this year, with more than one TD throw four times.
• Brissett also has run for 82 yards on 19 attempts with one touchdown, picking up 13.7 yards per game.

Recent Performances vs. the 49ers

Cardinals Home Splits

• The Cardinals’ average points scored in home games (22.8) is higher than their overall average (22.4). But their average points conceded at home (23.5) is lower than overall (23.9).
• The Cardinals accumulate 309 yards per game at home (7.3 less than their overall average), and give up 331.3 at home (8.1 less than overall).
• The Cardinals accumulate 200.8 passing yards per game in home games (2.1 less than their overall average), and give up 237.3 at home (12.0 more than overall).
• The Cardinals’ average rushing yards gained (108.3) and conceded (94) at home are both lower than their overall averages of 113.4 and 114.1, respectively.
• In home games, the Cardinals convert 42.6% of third downs and allow 35.8% to be converted by their opponent. That’s less than they convert (44.8%) and allow (38.3%) overall.