James Cook will look to make an impact for the Buffalo Bills when they take on the New Orleans Saints at 1 p.m. ET on Sunday in Week 4 of the 2025 NFL season. Below, we break down Cook’s stats and trends as they relate to his prop bets to help you find the top bets for the player and this contest.

James Cook Prop Lines

• Matchup: Buffalo Bills vs. New Orleans Saints
• Time: 1 p.m. ET
• Date: September 28, 2025
• Rushing yards prop: Over 78.5 (-111)
• Receiving yards prop: Over 13.5 (-114)

James Cook Stats and Trends

• Cook has carried the rock 53 times for a team-high 284 yards (94.7 ypg). He has scored four TDs on the ground.
• Cook’s rushing yards over/under is 78.5, compared to his season average of 94.7.
• Cook has gained over 78.5 yards on the ground two times this season.
• His rushing yards average of 94.7 is 32.2 higher than his over/under average (62.5).
• Cook has surpassed his rushing yards prop bet twice in three opportunities this year.
• He has scored a rushing touchdown in all three games this season (with multiple rushing TDs once).
• Cook has also reeled in nine balls for 71 yards (23.7 ypg).

Recent Performances vs. the Saints

Bills Home Splits

• The Bills put up 36 points per game in home games (two more than their overall average), and concede 30.5 at home (6.8 more than overall).
• The Bills’ average yards gained (428.5) and allowed (354) at home are both higher than their overall averages of 420 and 287.3, respectively.
• At home, the Bills rack up 296 passing yards per game and concede 170. That’s more than they gain (257) and allow (131.3) overall.
• At home, the Bills rack up 132.5 rushing yards per game and give up 184. That’s less than they gain overall (163), and more than they allow (156).
• The Bills’ offensive third-down percentage (50%) and defensive third-down percentage (61.5%) in home games are both higher than their overall averages of 45% and 43.2%, respectively.