The Notre Dame Fighting Irish (11-11, 2-7 ACC) visit the No. 24 Louisville Cardinals (15-6, 5-4 ACC) after losing four road games in a row. The Cardinals are double-digit favorites by 18.5 points in the matchup, which starts at 7 p.m. ET on Wednesday, February 4, 2026. The point total is 155.5 for the matchup.
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Louisville Cover -18.5 vs Notre Dame -110
Louisville vs. Notre Dame betting lines
- Louisville moneyline odds to win: -2500
- Notre Dame moneyline odds to win: +1166
- Spread: Louisville (-18.5)
- Total: 155.5
Louisville statistics, trends and more
As the home team
- Louisville owns a better record against the spread at home (8-5-0) than it does on the road (2-4-0).
- The Cardinals have hit the over on the over/under in five of 13 home games (38.5%), compared to two of six road games (33.3%).
- As a moneyline favorite, Louisville has picked up the win in 10 of 11 games when playing at home, good for a .909 winning percentage. It has won two of four games on the road (.500) as a moneyline favorite.
Recent trends
- The Cardinals’ offense has been worse over their last 10 games, scoring 80.3 points a contest compared to the 86.1 they’ve averaged this season.
- Louisville has been less stingy on the defensive side of the ball as of late, giving up 71.6 points per game over its past 10 contests compared to the 70.5 points per game its opponents are averaging over the 2025-26 season.
- During their last 10 outings, the Cardinals are making 0.9 fewer three-pointers per game than their season long average (10.9 compared to 11.8 season-long), while also shooting a lower percentage from beyond the arc in that span (33.4% compared to 34.8% season-long).
Louisville betting records this season
- ATS Record: 12-9-0 (Home: 8-5-0; Away: 2-4-0)
- ATS Record When Favored by 18.5+: 4-3-0 (As Favorite: 12-6-0; As Underdog: 0-3-0)
- O-U-P: 8-13-0 (Home: 5-8-0; Away: 2-4-0)
- Record When Moneyline Favorite: 14-3 (Home: 10-1; Away: 2-2)
- Record When Moneyline Underdog: 0-3 (Home: 0-1; Away: 0-2)
| Field Goal % | Opp. Field Goal % | Rebounds | Opp. Rebounds | Assists | Turnovers |
|---|---|---|---|---|---|
| 46.3 (119th in nation) | 40.4 (33rd) | 38.0 (12th) | 31.1 (183rd) | 17.6 (26th) | 11.3 (188th) |
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Notre Dame statistics, trends and more
As the away team
- In 2025-26 against the spread, Notre Dame has a lower winning percentage at home (.500, 6-6-0 record) than away (.571, 4-3-0).
- In terms of the over/under, Fighting Irish games have gone over more frequently at home (nine of 12, 75%) than away (five of seven, 71.4%).
- When moneyline underdogs, the Fighting Irish have won a lower percentage of games at home (1-3) than away (2-5).
Recent trends
- In their past 10 games, the Fighting Irish are averaging 69.9 points per contest, 4.1 fewer points than their season average (74.0).
- Notre Dame is ceding 77.1 points per game over its last 10 games, compared to its season average of 72.2 points allowed.
- The Fighting Irish are draining 1.0 fewer threes per contest over their last 10 games (7.4) compared to their season average (8.4), and they are posting a worse three-point percentage over their last 10 games (30.6%) compared to their season mark (35.2%).
Notre Dame betting records this season
- ATS Record: 11-11-0 (Home: 6-6-0; Away: 4-3-0)
- O-U-P: 14-8-0 (Home: 9-3-0; Away: 5-2-0)
- Record When Moneyline Favorite: 8-1 (Home: 7-1; Away: 0-0)
- Record When Moneyline Underdog: 3-10 (Home: 1-3; Away: 2-5)
| Field Goal % | Opp. Field Goal % | Rebounds | Opp. Rebounds | Assists | Turnovers |
|---|---|---|---|---|---|
| 45.0 (197th in nation) | 43.2 (144th) | 33.8 (102nd) | 28.4 (49th) | 12.0 (313th) | 10.9 (149th) |
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