The No. 19 Louisville Cardinals (22-6, 15-2 ACC) are heavy favorites (-10.5) as they try to continue an eight-game home winning streak when they square off against the Pittsburgh Panthers (16-12, 7-10 ACC) on Saturday, March 1, 2025 at KFC Yum! Center. The matchup airs at 6 p.m. ET on ESPN2. The matchup has an over/under of 150.5.

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Louisville vs. Pittsburgh betting lines

• Louisville moneyline odds to win: -613
• Pittsburgh moneyline odds to win: +445
• Spread: Louisville (-10.5)
• Total: 150.5

Louisville statistics, trends and more

As the home team

• Louisville has covered the spread in a lower percentage of its home games than away games. It has covered five times in 14 games when playing at home, and it has covered nine times in 11 games when playing on the road.
• In terms of over/unders, the Cardinals hit the over less often in home games, as they’ve exceeded the total five times in 14 opportunities this season (35.7%). On the road, they have hit the over five times in 11 opportunities (45.5%).
• Louisville has won a lower percentage of its matchups as a moneyline favorite when playing at home, going 11-2 (.846). In away games as a moneyline favorite, it sports a record of 6-1 (.857).

Recent trends

• The Cardinals’ offense has been better over their last 10 games, putting up 81.9 points per contest compared to the 79.5 they’ve averaged this season.
• Louisville’s defense has been tough lately, as the team has given up 68.5 points per game over its last 10 compared to the 69.3 points per game its opponents are averaging on the season.
• Over their last 10 outings, the Cardinals are making 0.3 more three-pointers per game than their season long average (10 compared to 9.7 season-long), while also shooting a higher percentage from beyond the arc in that span (36.2% compared to 32.7% season-long).

Louisville betting records this season

• ATS Record: 16-12-0 (Home: 5-9-0; Away: 9-2-0)
• ATS Record When Favored by 10.5+: 3-7-0 (As Favorite: 12-11-0; As Underdog: 4-1-0)
• O-U-P: 10-18-0 (Home: 5-9-0; Away: 5-6-0)
• Record When Moneyline Favorite: 18-4 (Home: 11-2; Away: 6-1)
• Record When Moneyline Underdog: 4-2 (Home: 0-1; Away: 3-1)

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Pittsburgh statistics, trends and more

As the away team

• Pittsburgh’s winning percentage against the spread at home is .500 (8-8-0). On the road, it is .300 (3-7-0).
• Panthers games have finished above the over/under 50% of the time at home (eight of 16), and 40% of the time on the road (four of 10).

Recent trends

• The Panthers are posting 70.3 points per game in their past 10 games, which is 6.5 fewer points than their average for the season (76.8).
• Pittsburgh has fared worse defensively in its past 10 games, ceding 72 points per contest, 0.7 more points than its season average of 71.3.
• The Panthers are sinking 0.8 fewer three-pointers per contest in their last 10 games (7.5) compared to their season average (8.3), and they are producing a worse three-point percentage over their last 10 contests (33.9%) compared to their season mark (35.3%).

Pittsburgh betting records this season

• ATS Record: 12-16-0 (Home: 8-8-0; Away: 3-7-0)
• ATS Record When Underdog by 10.5+: 0-1-0 (As Favorite: 9-13-0; As Underdog: 3-3-0)
• O-U-P: 13-14-1 (Home: 8-7-1; Away: 4-6-0)
• Record When Moneyline Favorite: 15-7 (Home: 12-4; Away: 2-2)
• Record When Moneyline Underdog: 1-5 (Home: 0-0; Away: 1-5)