The No. 19 Louisville Cardinals (5-1) host an ACC clash against the Boston College Eagles (1-6) on Saturday, October 25, 2025 at L&N Federal Credit Union Stadium.

The Eagles are expected to lose by at least two touchdowns (currently +25.5) against the Cardinals (with an over/under of 54.5 points).

Below you can find our betting primer for this this contest between the Cardinals and the Eagles, and find all of our expert picks here, too!

Louisville vs. Boston College betting lines

• Spread favorite: Cardinals (-25.5)
• Moneyline: Cardinals (-3125), Eagles (+1350)
• Total: 54.5 points
• TV Channel: ACC Network
• Live Stream: Fubo

Louisville vs. Boston College betting info and stats

Louisville has a pair of wins against the spread so far this season (2-4-0). Louisville has yet to cover the spread when serving as favorites by at least 25.5 points (a 0-2 ATS record). Louisville is 4-1 in the five games this season it has been moneyline favorites. Boston College has two wins against the spread this season (2-5-0). Boston College has played a game as an underdog on the moneyline four times this season, losing every game.

Louisville vs. Boston College recent stats and trends

Louisville Cardinals

• Louisville has covered the spread twice in its last three matchups while putting up a 2-1 record straight-up in those games.
• The final combined score of the last three Louisville games surpassed the set total once.
• The past three Louisville games averaged 0.7 more points (55.2) than this matchup’s point total.

Boston College Eagles

• Boston College has not covered a spread (0-3) while going 2-1 overall over its past three matchups.
• In one of those three games, the final combined score exceeded the set total.
• The past three Boston College games averaged 1.5 more points (56.0) than this matchup’s over/under.

Louisville vs. Boston College key players

Louisville Cardinals

• Miller Moss has thrown for 1,606 yards (267.7 ypg) to lead Louisville, completing 66.2% of his passes and collecting nine touchdown passes compared to four interceptions this season.
• Isaac Brown has 447 rushing yards on 61 carries with three touchdowns.
• Keyjuan Brown has been handed the ball 30 times this year and racked up 132 yards (26.4 per game) with three touchdowns.
• Chris Bell’s leads his squad with 638 yards as a receiver. He’s racked up that yardage on 44 catches (out of 66 targets) and scored six touchdowns.
• Caullin Lacy has grabbed 32 passes while averaging 54.3 yards per game.
• Jaleel Skinner has been the target of 17 passes and racked up 12 receptions for 137 yards, an average of 22.8 yards per contest. He’s found the end zone one time through the air this season.
• Clev Lubin has 3.5 sacks to pace the team, and also has 2.0 TFL and 27 tackles.
• D’Angelo Hutchinson is the team’s top-tackler this year. He’s collected 38 tackles, 1.0 TFL, and one interception.
• Antonio Watts has a team-leading three interceptions to go along with 22 tackles, 4.0 TFL, 2.5 sacks, and three passes defended.

Boston College Eagles

• Dylan Lonergan has thrown for 1,394 yards (232.3 per game) while completing 67% of his passes and recording nine touchdown passes with three interceptions this season.
• Turbo Richard has run for 431 yards on 88 carries so far this year while scoring five times on the ground. He’s also tacked on 19 catches, totaling 175 yards and two touchdowns in the passing game.
• Jordan McDonald has run for 221 yards across 50 carries, scoring one touchdown.
• Lewis Bond has registered 50 catches this season and his team-high yardage total sits at 505 (72.1 yards per game). He’s been targeted 65 times.
• Reed Harris has put together a 337-yard season so far with three touchdowns. He’s caught 20 passes on 37 targets.
• Jeremiah Franklin’s 26 receptions (on 43 targets) have netted him 266 yards (38.0 ypg) and one touchdown.
• Sedarius McConnell has 2.5 sacks to pace the team, and also has 3.0 TFL and 14 tackles.
• KP Price has been all over the field, leading the team in both tackles and interceptions. He has 40 tackles, 1.0 TFL, and one interception so far.