The No. 14 Louisville Cardinals (7-1) host an ACC showdown against the California Golden Bears (5-4) on Saturday, November 8, 2025 at L&N Federal Credit Union Stadium.

The Golden Bears are expected to lose by at least two TDs (currently +18.5) against the Cardinals (with an over/under of 49.5 points).

Read on for our betting primer for this this matchup between the Cardinals and the Golden Bears, and discover all of our betting picks here, too!

Louisville vs. Cal betting lines

• Spread favorite: Cardinals (-18.5)
• Moneyline: Cardinals (-1075), Golden Bears (+688)
• Total: 49.5 points
• TV Channel: ESPN2
• Live Stream: Fubo

Louisville vs. Cal betting info and stats

Louisville is 3-5-0 against the spread so far this season. Louisville is winless ATS (0-3) when favorites by at least 18.5 points. Louisville has been the moneyline favorite for seven games this season, and it has put together a 6-1 record in those matchups. Cal has three wins against the spread so far this season (3-6-0). Cal’s record when playing as an underdog this year is 2-3.

Louisville vs. Cal recent stats and trends

Louisville Cardinals

• Louisville is 2-1 against the spread in its past three games, and has a 3-0 straight-up record in those matchups.
• One time in those three games, the final combined score went over the set total.
• The past three Louisville games averaged 2.7 more points (52.2) than this matchup’s over/under.

California Golden Bears

• Cal is winless against the spread (0-3) and 3-0 overall in its past three contests.
• The final combined score of the past three Cal games went over the set total one time.
• The past three Cal games averaged 0.3 more points (49.8) than this matchup’s point total.

Louisville vs. Cal key players

Louisville Cardinals

• Miller Moss has thrown for 1,929 yards (241.1 ypg) to lead Louisville, completing 65.3% of his passes and collecting 11 touchdown passes compared to six interceptions this season.
• The team’s top rusher, Isaac Brown, has carried the ball 91 times for 782 yards (97.8 per game), scoring five times.
• Keyjuan Brown has collected 321 yards on 52 attempts, scoring six times. He’s grabbed eight passes for 99 yards (16.5 per game), as well.
• Chris Bell’s leads his squad with 743 yards as a receiver. He’s racked up that yardage on 56 catches (out of 85 targets) and scored six touchdowns.
• Caullin Lacy has caught 44 passes for 422 yards (52.8 yards per game) and two touchdowns this year.
• Jaleel Skinner has a total of 155 receiving yards so far this year, hauling in 13 passes and scoring one touchdown.
• Wesley Bailey has 4.0 sacks to pace the team, and also has 3.0 TFL and 31 tackles.
• Louisville’s leading tackler, TJ Quinn, has 57 tackles, 3.0 TFL, one sack, and two interceptions this year.
• Antonio Watts leads the team with three interceptions, while also collecting 30 tackles, 4.0 TFL, 2.5 sacks, and three passes defended.

California Golden Bears

• Jaron-Keawe Sagapolutele leads Cal with 2,187 yards on 193-of-316 passing with 11 touchdowns compared to nine interceptions this season.
• The team’s top rusher, Kendrick Raphael, has carried the ball 149 times for 621 yards (69.0 per game) with 10 touchdowns. He’s also caught 17 passes for 129 yards and one touchdown.
• LJ Johnson Jr. has run for 108 yards across 33 attempts, scoring two touchdowns.
• Jacob De Jesus leads his team with 533 receiving yards on 56 catches with three touchdowns.
• Trond Grizzell has caught 34 passes and compiled 528 receiving yards (58.7 per game) with one touchdown.
• Mason Mini’s 50 targets have resulted in 34 catches for 382 yards and four touchdowns.
• Cade Uluave, the team’s tackle and sacks leader, has collected 3.0 sacks, 9.0 TFL and 66 tackles.
• Hezekiah Masses has a team-leading four interceptions to go along with 23 tackles, 1.0 TFL, and four passes defended.