The Louisville Cardinals (7-4) and the Kentucky Wildcats (5-6) meet at L&N Federal Credit Union Stadium on Saturday, November 29, 2025.
The Wildcats are underdogs, but by less than a field goal (+1.5), versus the Cardinals (with an over/under of 46.5 points).
Below you can find our betting preview for this this matchup between the Cardinals and the Wildcats, and discover all of our expert predictions here, too!
To Cover the Spread
Bet $20, Payout $38.35
Louisville -1.5 vs. Kentucky
Louisville vs. Kentucky betting lines
- Spread favorite: Cardinals (-1.5)
- Moneyline: Cardinals (-120), Wildcats (-100)
- Total: 46.5 points
- TV Channel: ACC Network
- Live Stream: Fubo
Louisville vs. Kentucky betting info and stats
- Louisville, through 11 games with a spread so far this season, has gone 3-8-0 against the spread. Louisville has covered the spread twice this season when listed as the favorite by at least 1.5 points. Louisville has been named as moneyline favorites nine times this season, and has put together a 6-3 record in those outings. Kentucky has a 5-6-0 record against the spread so far this season. Kentucky has gone 4-4 ATS when it is an underdog by 1.5 points or more. This will be the ninth time this year Kentucky is the moneyline underdog and has gone 2-6 in such contests.
Louisville vs. Kentucky recent stats and trends
Louisville Cardinals
- Louisville is winless against the spread over its last three games, and has a 0-3 straight-up record in those matchups.
- In one of those three games, the final combined score exceeded the set total.
- The past three Louisville games averaged 3.7 more points (50.2) than this matchup’s point total.
Kentucky Wildcats
- Kentucky is 2-1 against the spread over its last three games and has a 0-3 straight-up record in those contests.
- Kentucky and its opponents have combined to hit the over all three times in those games.
- Kentucky’s past three games have ended with an average of 50.0 points scored. That’s 3.5 more points than this contest’s over/under.
Louisville vs. Kentucky key players
Louisville Cardinals
- Miller Moss has thrown for 2,344 yards (234.4 ypg) to lead Louisville, completing 64.3% of his passes and collecting 11 touchdown passes compared to seven interceptions this season.
- Isaac Brown has carried the ball 91 times for a team-high 782 yards on the ground and has found the end zone five times.
- Keyjuan Brown has been handed the ball 81 times this year and racked up 592 yards (65.8 per game) with six touchdowns.
- Chris Bell has hauled in 72 catches for 917 yards (83.4 yards per game) to lead the team so far this season. He’s found the end zone six times as a receiver.
- Caullin Lacy has put up a 547-yard season so far with two touchdowns, hauling in 54 passes on 73 targets.
- Dacari Collins has racked up 11 catches for 179 yards, an average of 19.9 yards per game.
- Wesley Bailey has 5.0 sacks to lead the team, and also has 4.0 TFL and 35 tackles.
- TJ Quinn, Louisville’s leading tackler, has 67 tackles, 3.0 TFL, one sack, and two interceptions this year.
- Antonio Watts has a team-leading three interceptions to go along with 37 tackles, 5.0 TFL, 2.5 sacks, and three passes defended.
Kentucky Wildcats
- Cutter Boley leads Kentucky with 2,060 yards on 185-of-275 passing with 15 touchdowns compared to 10 interceptions this season. He has chipped in with 114 rushing yards (11.4 ypg) on 57 carries while scoring two touchdowns on the ground.
- The team’s top rusher, Seth McGowan, has carried the ball 163 times for 720 yards (72.0 per game) with 12 touchdowns.
- Dante Dowdell has totaled 533 yards on 106 carries with three touchdowns.
- Kendrick Law has totaled 50 catches this season and his team-high yardage total sits at 524 (47.6 yards per game). He’s been targeted 62 times and has three touchdowns.
- Willie Rodriguez has put together a 295-yard season so far with one touchdown. He’s caught 22 passes on 39 targets.
- Hardley Gilmore IV has racked up 287 reciving yards (28.7 ypg) and one touchdown this season.
- Steven Soles Jr. has 3.5 sacks to lead the team, and also has 1.0 TFL and 10 tackles.
- Daveren Rayner is the team’s tackle leader this year. He’s totaled 65 tackles, 6.0 TFL, two sacks, and two interceptions.
- Ty Bryant leads the team with four interceptions, while also putting up 62 tackles, 1.0 TFL, and four passes defended.
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