The Louisville Cardinals (4-0) square off against a fellow ACC opponent when they host the No. 24 Virginia Cavaliers (4-1) on Saturday, October 4, 2025 at L&N Federal Credit Union Stadium.

The Cavaliers are underdogs, but by less than a touchdown (+6.5), versus the Cardinals (with an over/under of 60.5 points).

Keep reading to check out our betting primer for this this contest between the Cardinals and the Cavaliers, and uncover all of our predictions here, too!

Louisville vs. Virginia betting lines

• Spread favorite: Cardinals (-6.5)
• Moneyline: Cardinals (-248), Cavaliers (+203)
• Total: 60.5 points
• TV Channel: ESPN2
• Live Stream: Fubo

Louisville vs. Virginia betting info and stats

Louisville has one win against the spread so far this season (1-3-0). Louisville has yet to cover the spread when playing as the favorite by at least 6.5 points (a 0-3 ATS record). Louisville has been listed the moneyline favorite four times this season, and has put up a 4-0 record in those matchups. Virginia has four wins against the spread this season (4-1-0). When Virginia is an underdog of 6.5 points or more, it has always covered the spread (1-0 ATS). Virginia has been an underdog on the moneyline two times this season, and it split the two games.

Louisville vs. Virginia recent stats and trends

Louisville Cardinals

Virginia Cavaliers

• Virginia is a perfect 3-0 against the spread over its past three games, and has a 3-0 straight-up record in those contests.
• In each of those games, the final combined score has surpassed the set total.
• Virginia’s past three games have ended with an average of 54.5 points scored. That’s 6.0 fewer points than this contest’s over/under.

Louisville vs. Virginia key players

Louisville Cardinals

• Miller Moss has thrown for 1,029 yards (257.3 ypg) to lead Louisville, completing 65.6% of his passes and collecting five touchdown passes compared to three interceptions this season.
• Isaac Brown has carried the ball 33 times for a team-high 268 yards on the ground and has found the end zone three times as a runner.
• Keyjuan Brown has racked up 110 yards on 22 attempts, scoring three times. He’s caught four passes for 47 yards (23.5 per game), as well.
• Chris Bell’s leads his squad with 332 yards as a receiver. He’s racked up that yardage on 23 catches (out of 40 targets) and scored two touchdowns.
• Caullin Lacy has hauled in 22 receptions totaling 266 yards so far this campaign.
• Dacari Collins’ six receptions have yielded 105 yards.
• Clev Lubin paces the team with 3.5 sacks. He’s also the team’s tackle leader, and has recorded 2.0 TFL and 21 tackles.
• Antonio Watts has a team-leading two interceptions to go along with 13 tackles, 1.0 TFL, 1.5 sacks, and two passes defended.

Virginia Cavaliers

• Chandler Morris leads Virginia with 1,279 yards on 111-of-155 passing with 10 touchdowns compared to four interceptions this season. He has chipped in with 169 rushing yards (33.8 ypg) on 22 carries while scoring four touchdowns on the ground.
• The team’s top rusher, J’mari Taylor, has carried the ball 75 times for 397 yards (79.4 per game) with seven touchdowns.
• Harrison Waylee has been given 30 carries and totaled 229 yards with four touchdowns.
• Trell Harris leads his team with 366 receiving yards on 21 catches with three touchdowns.
• Cameron Ross has put up a 286-yard season so far with one touchdown. He’s caught 24 passes on 34 targets.
• Jahmal Edrine has racked up 214 reciving yards (42.8 ypg) and one touchdown this season.
• Daniel Rickert has racked up 3.5 sacks to lead the team, while also recording 3.0 TFL and 12 tackles.
• Virginia’s leading tackler, Devin Neal, has 24 tackles, 1.0 TFL, and 0.5 sacks this year.
• Ja’Son Prevard leads the team with two interceptions, while also putting up seven tackles and two passes defended.