ACC foes meet when the No. 16 Louisville Cardinals (6-1) and the Virginia Tech Hokies (3-5) play on Saturday, November 1, 2025 at Lane Stadium.

The Cardinals are double-digit favorites (currently -10.5) in their game against the Hokies, with the over/under at 53.5 points. (In terms of the moneyline, the Cardinals are -397 and the Hokies are +312.)

Keep reading to check out our preview for this this contest between the Cardinals and the Hokies, and discover all of our predictions here, too!

Louisville vs. Virginia Tech betting lines

• Spread favorite: Cardinals (-10.5)
• Moneyline: Cardinals (-397), Hokies (+312)
• Total: 53.5 points
• TV Channel: CW (WGN – Chicago)
• Live Stream: Fubo

Louisville vs. Virginia Tech betting info and stats

Louisville has two wins against the spread this season (2-5-0). Louisville has yet to cover the spread when playing as favorites by at least 10.5 points (a 0-4 ATS record). In six games as the moneyline favorite, Louisville is 5-1. Virginia Tech, in eight games with a set spread so far this season, has gone 2-6-0 against the spread. Virginia Tech has not covered the spread in games it was the underdog by at least 10.5 points (0-1). Virginia Tech is 1-2 in games it has been an underdog on the moneyline.

Louisville vs. Virginia Tech recent stats and trends

Louisville Cardinals

• Louisville has covered the spread once in its last three contests while putting together a 2-1 record straight-up in those games.
• The final combined score of the past three Louisville games went over the set total one time.
• The past three Louisville games averaged 1.3 more points (54.8) than this matchup’s over/under.

Virginia Tech Hokies

• Virginia Tech is 1-2 against the spread in its last three games, and has a 2-1 straight-up record in those matchups.
• The final combined score of the past three Virginia Tech games has surpassed the set total twice.
• Virginia Tech’s last three games have ended with an average of 52.5 points scored. That’s 1.0 fewer point than this contest’s over/under.

Louisville vs. Virginia Tech key players

Louisville Cardinals

• Miller Moss has 1,793 passing yards for Louisville, completing 65% of his passes and tossing 10 touchdowns and five interceptions this season.
• Isaac Brown has carried the ball 75 times for a team-high 652 yards on the ground and has found the end zone four times.
• Keyjuan Brown has been handed the ball 40 times this year and racked up 227 yards (37.8 per game) with four touchdowns. He’s also helped out in the pass game with seven grabs for 97 yards
• Chris Bell’s leads his squad with 687 yards as a receiver. He’s racked up that yardage on 48 catches (out of 76 targets) and scored six touchdowns.
• Caullin Lacy has grabbed 38 passes while averaging 52.7 yards per game and scoring one touchdown.
• Jaleel Skinner has a total of 155 receiving yards so far this year, grabbing 13 passes and scoring one touchdown.
• Wesley Bailey leads the team with 4.0 sacks, and also has 3.0 TFL and 27 tackles.
• D’Angelo Hutchinson is the team’s leading tackler this year. He’s racked up 47 tackles, 2.0 TFL, and one interception.
• Antonio Watts has picked off a team-leading three passes. He also has 27 tackles, 4.0 TFL, 2.5 sacks, and three passes defended to his name.

Virginia Tech Hokies

• Kyron Drones has thrown for 1,516 yards (189.5 ypg) to lead Virginia Tech, completing 59.7% of his passes and recording 14 touchdown passes and six interceptions this season. He is also a playmaker on the ground, racking up 414 yards (51.8 ypg) on 113 carries with seven touchdowns.
• The team’s top rusher, Marcellous Hawkins, has carried the ball 85 times for 531 yards (66.4 per game) with one touchdown.
• Ayden Greene has collected 23 catches this season and his team-high yardage total sits at 365 (45.6 yards per game). He’s been targeted 47 times and has two touchdowns.
• Donavon Greene has put up a 267-yard season so far with two touchdowns. He’s caught 16 passes on 31 targets.
• Takye Heath’s 15 catches (on 23 targets) have netted him 157 yards (31.4 ypg) and three touchdowns.
• Kemari Copeland has 4.0 sacks to pace the team, and also has 4.0 TFL, 30 tackles, and one interception.
• Virginia Tech’s top-tackler, Kaleb Spencer, has 32 tackles, 3.0 TFL, and 0.5 sacks this year.
• Quentin Reddish has picked off a team-leading one pass. He also has 11 tackles and one pass defended to his name.