ACC foes match up when the No. 2 Miami Hurricanes (5-0) and the Louisville Cardinals (4-1) square off on Friday, October 17, 2025 at Hard Rock Stadium.

The Hurricanes are double-digit favorites (currently -13.5) in their game versus the Cardinals, with the over/under at 50.5 points. (On the moneyline, the Hurricanes are -575 and the Cardinals are +421.)

Below you’ll find our betting primer for this this contest between the Hurricanes and the Cardinals, and uncover all of our betting picks here, too!

Miami (FL) vs. Louisville betting lines

• Spread favorite: Hurricanes (-13.5)
• Moneyline: Hurricanes (-575), Cardinals (+421)
• Total: 50.5 points
• TV Channel: ESPN
• Live Stream: Fubo

Miami (FL) vs. Louisville betting info and stats

Miami (FL) has an against-the-spread record of 4-1-0 so far this season. Miami (FL) has covered the spread once this season when favored by at least 13.5 points. Miami (FL) has put up a 4-0 record in the four games this season it has been favored on the moneyline. Louisville has won just one game against the spread so far this season (1-4-0). This is the first time on the year Louisville is an underdog on the moneyline.

Miami (FL) vs. Louisville recent stats and trends

Miami Hurricanes

• Miami (FL) is a perfect 3-0 against the spread over its past three games, and has a 3-0 straight-up record in those contests.
• In one of those three games, the final combined score went over the set total.
• The last three Miami (FL) games averaged 54.0 total points, 3.5 more points than this matchup’s over/under.

Louisville Cardinals

• Louisville is 1-2 against the spread in its past three games, and has a 3-0 straight-up record in those contests.
• Two times in those three games, the final combined score has exceeded the set total.
• The past three Louisville games averaged 5.3 more points (55.8) than this matchup’s point total.

Miami (FL) vs. Louisville key players

Miami Hurricanes

• Carson Beck has 1,213 yards passing for Miami (FL), completing 72.9% of his passes and recording 11 touchdowns and three interceptions this season.
• Mark Fletcher has 428 rushing yards on 78 carries with five touchdowns.
• CharMar Brown has piled up 210 yards on 57 attempts, scoring four times. He’s caught eight passes for 75 yards (18.8 per game) and one touchdown, as well.
• Malachi Toney’s team-high 375 yards as a receiver have come on 29 catches (out of 37 targets) with three touchdowns.
• CJ Daniels has caught 23 passes while averaging 53.8 yards per game and scoring five touchdowns.
• Keelan Marion has hauled in 11 catches for 125 yards, an average of 25.0 yards per game.
• Akheem Mesidor has racked up 3.5 sacks to pace the team, while also recording 3.0 TFL and 21 tackles.
• Miami (FL)’s tackle leader, Rueben Bain Jr., has 23 tackles, 1.0 TFL, two sacks, and one interception this year.
• Bryce Fitzgerald leads the team with three interceptions, while also putting up five tackles and three passes defended.

Louisville Cardinals

• Miller Moss has recored 1,358 passing yards, or 271.6 per game, so far this season. He has completed 67% of his passes and has tossed seven touchdowns with four interceptions.
• Isaac Brown is his team’s leading rusher with 46 carries for 334 yards, or 66.8 per game. He’s found the end zone three times on the ground, as well.
• Keyjuan Brown has piled up 126 yards (on 25 attempts) with three touchdowns, while also catching five passes for 47 yards.
• Chris Bell’s 502 receiving yards (100.4 yards per game) are a team high. He has 35 catches on 54 targets with four touchdowns.
• Caullin Lacy has recorded 287 receiving yards (57.4 yards per game) on 27 receptions.
• Jaleel Skinner has racked up 137 reciving yards (27.4 ypg) and one touchdown this season.
• Clev Lubin has 3.5 sacks to lead the team, and also has 2.0 TFL and 24 tackles.
• D’Angelo Hutchinson is the team’s tackle leader this year. He’s amassed 32 tackles, 1.0 TFL, and one interception.
• Antonio Watts has a team-high two interceptions to go along with 19 tackles, 3.0 TFL, 2.5 sacks, and two passes defended.