The NBA lineup on Wednesday is not one to miss. The outings include the Cleveland Cavaliers squaring off against the New York Knicks at Madison Square Garden.
For a breakdown of all the important games in the NBA on Wednesday, check out our betting odds preview below.
Below you can find our previews for this season, and uncover all of our betting picks here, too!
Wednesday’s Closest Projected NBA Games (by Spread)
Cleveland Cavaliers (0-0) at New York Knicks (0-0)
- Game Time: 7:00 PM ET | Wednesday, October 22, 2025
- Knicks Last Season: Lost in Conference Finals
- Cavs Last Season: Lost in Conference Semifinals
Cavaliers -1.5 vs. Knicks
San Antonio Spurs (0-0) at Dallas Mavericks (0-0)
- Game Time: 9:30 PM ET | Wednesday, October 22, 2025
- Mavs Last Season: Missed Postseason
- Spurs Last Season: Missed Postseason
Mavericks -3 vs. Spurs
Detroit Pistons (0-0) at Chicago Bulls (0-0)
- Game Time: 8:00 PM ET | Wednesday, October 22, 2025
- Bulls Last Season: Missed Postseason
- Pistons Last Season: Lost in First Round
Pistons -3.5 vs. Bulls
New Orleans Pelicans (0-0) at Memphis Grizzlies (0-0)
- Game Time: 8:00 PM ET | Wednesday, October 22, 2025
- Grizzlies Last Season: Lost in First Round
- Pelicans Last Season: Missed Postseason
Grizzlies -4 vs. Pelicans
Sacramento Kings (0-0) at Phoenix Suns (0-0)
- Game Time: 10:00 PM ET | Wednesday, October 22, 2025
- Suns Last Season: Missed Postseason
- Kings Last Season: Missed Postseason
Suns -4 vs. Kings
Philadelphia 76ers (0-0) at Boston Celtics (0-0)
- Game Time: 7:30 PM ET | Wednesday, October 22, 2025
- Celtics Last Season: Lost in Conference Semifinals
- Sixers Last Season: Missed Postseason
Celtics -4.5 vs. 76ers
Minnesota Timberwolves (0-0) at Portland Trail Blazers (0-0)
- Game Time: 10:00 PM ET | Wednesday, October 22, 2025
- Blazers Last Season: Missed Postseason
- T-Wolves Last Season: Lost in Conference Finals
Timberwolves -4.5 vs. Trail Blazers
Brooklyn Nets (0-0) at Charlotte Hornets (0-0)
- Game Time: 7:00 PM ET | Wednesday, October 22, 2025
- Hornets Last Season: Missed Postseason
- Nets Last Season: Missed Postseason
Hornets -5.5 vs. Nets
Toronto Raptors (0-0) at Atlanta Hawks (0-0)
- Game Time: 7:30 PM ET | Wednesday, October 22, 2025
- Hawks Last Season: Missed Postseason
- Raptors Last Season: Missed Postseason
Hawks -5.5 vs. Raptors
Miami Heat (0-0) at Orlando Magic (0-0)
- Game Time: 7:00 PM ET | Wednesday, October 22, 2025
- Magic Last Season: Lost in First Round
- Heat Last Season: Lost in First Round
Magic -8.5 vs. Heat
Los Angeles Clippers (0-0) at Utah Jazz (0-0)
- Game Time: 9:00 PM ET | Wednesday, October 22, 2025
- Jazz Last Season: Missed Postseason
- Clippers Last Season: Lost in First Round
Clippers -9.5 vs. Jazz
Washington Wizards (0-0) at Milwaukee Bucks (0-0)
- Game Time: 8:00 PM ET | Wednesday, October 22, 2025
- Bucks Last Season: Lost in First Round
- Wizards Last Season: Missed Postseason
Bucks -10 vs. Wizards
BetDecider Team
The BetDecider team brings you the most current sports betting content, with expert insights and tips. Our aim is that you can make an informed betting decision, including best odds and exclusive sportsbook offers, to maximize your betting experience.
