The Northwestern Wildcats (1-2) play a conference opponent when they host the UCLA Bruins (0-3) on Saturday, September 27, 2025 at Northwestern Medicine Field at Martin Stadium in a Big Ten clash.

The Wildcats are the favorites (-6.5) in their matchup versus the Bruins, with the over/under at 45.5 points. (On the moneyline, the Wildcats are -222 and the Bruins are +182.)

Below you’ll find our preview for this this contest between the Wildcats and the Bruins, and discover all of our predictions here, too!

Northwestern vs. UCLA betting lines

• Spread favorite: Wildcats (-6.5)
• Moneyline: Wildcats (-222), Bruins (+182)
• Total: 45.5 points
• TV Channel: Big Ten Network
• Live Stream: Fubo

Northwestern vs. UCLA betting info and stats

Northwestern has two wins against the spread this season (2-1-0). Northwestern has always covered the spread when it served as favorites by at least 6.5 points (a 1-0 ATS record). In one game as a moneyline favorite, Northwestern won. UCLA has not won a game against the spread this season (0-3-0). UCLA has played as the underdog on the moneyline once this season, and failed to pick up the victory.

Northwestern vs. UCLA key players

Northwestern Wildcats

• Preston Stone has thrown for 541 yards (180.3 ypg) to lead Northwestern, completing 59.3% of his passes and collecting three touchdown passes compared to six interceptions this season.
• Caleb Komolafe has 150 rushing yards on 36 carries with one touchdown.
• Cam Porter has collected 137 yards on 18 carries, scoring one time. He’s grabbed three passes for 23 yards (23.0 per game), as well.
• Griffin Wilde has hauled in 15 catches for 213 yards (71.0 yards per game) to lead the team so far this season. .
• Ricky Ahumaraeze has caught four passes for 73 yards (24.3 yards per game) this year.
• Joseph Himon II has hauled in seven catches for 59 yards, an average of 19.7 yards per game.
• Carmine Bastone has racked up 1.5 sacks to lead the team, while also recording 1.0 TFL and eight tackles.
• Robert Fitzgerald, Northwestern’s top tackler, has 26 tackles this year.
• Mac Uihlein has a team-leading two interceptions to go along with 20 tackles, 2.0 TFL, and two passes defended.

UCLA Bruins

• Nico Iamaleava has thrown for 608 yards (202.7 ypg) to lead UCLA, completing 63.9% of his passes and tossing three touchdown passes and three interceptions this season. He is also a playmaker on the ground, racking up 139 yards (46.3 ypg) on 30 carries with one touchdown.
• Anthony Woods has 10 receptions for 91 yards (30.3 per game) and one touchdown so far while also carrying the ball 21 times for 117 yards.
• Kwazi Gilmer has totaled 16 catches this season and his team-high yardage total sits at 174 (58.0 yards per game). He’s been targeted 25 times.
• Mikey Matthews has caught 10 passes and compiled 123 receiving yards (41.0 per game).
• Anthony Jones has 1.0 sack to pace the team, and also has 1.0 TFL and six tackles.
• Isaiah Chisom is the team’s top-tackler this year. He’s racked up 28 tackles and 1.0 TFL.