The No. 1 Ohio State Buckeyes (12-0) and No. 2 Indiana Hoosiers (12-0) will battle in the Big Ten Championship Game on Saturday, December 6, 2025.

The Buckeyes are favored, but by less than a touchdown (-4.5), versus the Hoosiers. The over/under for this game is 46.5 points.

Keep reading for our betting preview for this this matchup between the Buckeyes and the Hoosiers, and uncover all of our expert predictions here, too!

Ohio State vs. Indiana betting lines

• Spread favorite: Buckeyes (-4.5)
• Moneyline: Buckeyes (-192), Hoosiers (+159)
• Total: 46.5 points
• TV Channel: FOX 4K
• Live Stream: Fubo

Ohio State vs. Indiana betting info and stats

Ohio State has an against-the-spread record of 10-2-0 this season. Ohio State is 9-2 ATS this season when the favorite by 4.5 points or more. In 11 games as the moneyline favorite, Ohio State is 11-0. Indiana has seven wins against the spread this season (7-5-0). When Indiana is an underdog of 4.5 points or more, it has always covered the spread (1-0 ATS). This will be the second game this year Indiana is an underdog on the moneyline. The Hoosiers won the first one.

Ohio State vs. Indiana recent stats and trends

Ohio State Buckeyes

• Ohio State has covered the spread in its past three contests while putting up a 3-0 record straight-up in those games.
• The final combined score of the last three Ohio State games went over the set total one time.
• Ohio State’s last three games have ended with an average of 48.2 points scored. That’s 1.7 more points than this contest’s over/under.

Indiana Hoosiers

• Indiana has covered the spread once in its past three matchups while putting together a 3-0 record straight-up in those games.
• Twice in those three games, the final combined score has surpassed the set total.
• Indiana’s last three outings have ended with an average of 49.5 points scored. That’s 3.0 more points than this contest’s over/under.

Ohio State vs. Indiana key players

Ohio State Buckeyes

• Julian Sayin has 3,065 pass yards for Ohio State, completing 78.9% of his passes and recording 30 touchdowns and five interceptions this season.
• Bo Jackson has carried the ball 151 times for a team-high 952 yards on the ground and has found the end zone five times as a runner. He’s also tacked on 17 catches for 187 yards (23.4 per game) and one touchdown in the pass game.
• This season, James Peoples has carried the ball 61 times for 344 yards (34.4 per game) and three touchdowns.
• Jeremiah Smith’s team-leading 942 yards as a receiver have come on 72 receptions (out of 91 targets) with 11 touchdowns.
• Carnell Tate has hauled in 44 receptions totaling 793 yards, finding the end zone eight times as a receiver so far this campaign.
• Max Klare has racked up 41 receptions for 420 yards, an average of 35.0 yards per game. He’s scored two times as a receiver this season.
• Caden Curry has 9.0 sacks to lead the team, and also has 12.0 TFL and 47 tackles.
• Ohio State’s tackle leader, Sonny Styles, has 64 tackles, 4.0 TFL, 0.5 sacks, and one interception this year.
• Jermaine Mathews Jr. has picked off a team-high two passes. He also has 17 tackles, 1.0 TFL, one sack, and two passes defended to his name.

Indiana Hoosiers

• Fernando Mendoza leads Indiana with 2,758 yards on 211-of-293 passing with 32 touchdowns compared to five interceptions this season. He has chipped in with 243 rushing yards (20.3 ypg) on 64 carries while scoring six touchdowns on the ground.
• The team’s top rusher, Roman Hemby, has carried the ball 163 times for 866 yards (72.2 per game) with six touchdowns. He’s also caught 13 passes for 153 yards.
• Kaelon Black has piled up 729 yards (on 127 attempts) with seven touchdowns.
• Omar Cooper Jr. has hauled in 828 receiving yards on 59 catches to pace his team so far this season while scoring 11 touchdowns as a receiver.
• Elijah Sarratt has put together a 626-yard season so far with 11 touchdowns. He’s caught 47 passes on 68 targets.
• E.J. Williams’ 50 targets have resulted in 33 catches for 404 yards and five touchdowns.
• Rolijah Hardy leads the team with 7.0 sacks. He’s also the team’s tackle leader, and has amassed 10.0 TFL and 64 tackles.
• Amare Ferrell leads the team with four interceptions, while also collecting 33 tackles, 2.0 TFL, and four passes defended.