The No. 1 Ohio State Buckeyes (8-0) and the Purdue Boilermakers (2-7) square off on Saturday, November 8, 2025 at Ross-Ade Stadium in a clash of Big Ten foes.

The Buckeyes are expected to win by at least two TDs (currently -29.5) against the Boilermakers. The over/under for this game is 50.5 points.

Below you can find our betting preview for this this contest between the Buckeyes and the Boilermakers, and uncover all of our expert picks here, too!

Ohio State vs. Purdue betting lines

• Spread favorite: Buckeyes (-29.5)
• Moneyline: Buckeyes (-8333), Boilermakers (+2200)
• Total: 50.5 points
• TV Channel: Big Ten Network
• Live Stream: Fubo

Ohio State vs. Purdue betting info and stats

Ohio State has seven wins against the spread through eight opportunities this season (7-1-0). Ohio State is undefeated ATS (1-0) when favored by at least 29.5 points. Ohio State has been favored on the moneyline seven times this season, winning every game. Purdue is 4-5-0 against the spread this season. This will be the seventh game this year Purdue is the moneyline underdog, and have lost every such contest.

Ohio State vs. Purdue recent stats and trends

Ohio State Buckeyes

• Ohio State has covered the spread in its last three matchups while putting up a 3-0 record straight-up in those games.
• The final combined score of the past three Ohio State games went over the set total once.
• The past three Ohio State games averaged 4.7 fewer points (45.8) than this matchup’s point total.

Purdue Boilermakers

• Purdue is 1-2 against the spread and 3-0 overall in its last three games.
• In all of those games, the final combined score fell short of the set total.
• The last three Purdue games averaged 52.2 total points, 1.7 more points than this matchup’s point total.

Ohio State vs. Purdue key players

Ohio State Buckeyes

• Julian Sayin has thrown for 2,188 yards (273.5 ypg) to lead Ohio State, completing 80.7% of his passes and recording 23 touchdown passes compared to three interceptions this season.
• The team’s top rusher, Bo Jackson, has carried the ball 81 times for 538 yards (76.9 per game), scoring two times. He’s also caught 11 passes for 114 yards and one touchdown.
• CJ Donaldson has piled up 266 yards on 67 attempts, scoring seven times.
• Jeremiah Smith’s team-high 725 yards as a receiver have come on 55 receptions (out of 71 targets) with nine touchdowns.
• Carnell Tate has put up a 711-yard season so far with seven touchdowns, hauling in 39 passes on 47 targets.
• Max Klare has been the target of 26 passes and racked up 21 catches for 210 yards, an average of 26.3 yards per contest. He’s found the end zone one time through the air this season.
• Caden Curry has 7.0 sacks to lead the team, and also has 10.0 TFL and 36 tackles.
• Arvell Reese, Ohio State’s top tackler, has 55 tackles, 8.0 TFL, and 6.5 sacks this year.
• Caleb Downs has a team-high two interceptions to go along with 39 tackles, 3.0 TFL, and two passes defended.

Purdue Boilermakers

• Ryan Browne leads Purdue with 1,822 yards on 163-of-266 passing with nine touchdowns compared to seven interceptions this season. He has chipped in with 168 rushing yards (18.7 ypg) on 57 carries while scoring four touchdowns on the ground.
• Devin Mockobee has rushed for 521 yards on 125 carries so far this year while scoring four times on the ground. He’s also added 18 catches, totaling 215 yards and one touchdown in the passing game.
• Malachi Thomas has compiled 206 yards on 39 carries, while also catching nine passes for 93 yards and two scores.
• Michael Jackson III’s 456 receiving yards (50.7 yards per game) are a team high. He has 50 receptions on 62 targets with one touchdown.
• Nitro Tuggle has put up a 353-yard season so far with four touchdowns. He’s caught 24 passes on 45 targets.
• Corey Smith’s 14 grabs (on 24 targets) have netted him 237 yards (29.6 ypg) and one touchdown.
• CJ Nunnally has racked up 5.0 sacks to lead the team, while also recording 6.0 TFL and 32 tackles.
• Purdue’s leading tackler, Mani Powell, has 72 tackles, 5.0 TFL, and three sacks this year.
• Myles Slusher leads the team with one interception, while also collecting 47 tackles, 1.0 TFL, one sack, and one pass defended.