The No. 14 Oklahoma Sooners (5-1) hit the road for an SEC battle against the South Carolina Gamecocks (3-3) on Saturday, October 18, 2025 at Williams-Brice Stadium.

The Gamecocks are underdogs, but by less than a touchdown (+4.5), against the Sooners (with an over/under of 42.5 points).

Below you can find our betting preview for this this game between the Sooners and the Gamecocks, and find all of our expert picks here, too!

Oklahoma vs. South Carolina betting lines

• Spread favorite: Sooners (-4.5)
• Moneyline: Sooners (-187), Gamecocks (+156)
• Total: 42.5 points
• TV Channel: SEC Network
• Live Stream: Fubo

Oklahoma vs. South Carolina betting info and stats

Oklahoma is 3-3-0 against the spread so far this season. Oklahoma has covered the spread two times when the favorite by at least 4.5 points (a 2-2 ATS record). Oklahoma has recorded a 3-0 record in the three games this season it has been favored on the moneyline. South Carolina has three wins against the spread this season (3-3-0). In the two games South Carolina has been an underdog by at least 4.5 points, it covered the spread once. This is the third time this year South Carolina is an underdog on the moneyline, after losing the previous two such games.

Oklahoma vs. South Carolina recent stats and trends

Oklahoma Sooners

• Oklahoma is 1-2 against the spread in its last three games, and has a 2-1 straight-up record in those contests.
• Oklahoma and its opponents did not combine to hit the over in any of those games.
• The last three Oklahoma games averaged 48.5 total points, 6.0 more points than this matchup’s point total.

South Carolina Gamecocks

• South Carolina is 2-1 against the spread and 2-1 overall in its last three contests.
• The final combined score of the past three South Carolina games has gone over the set total twice.
• South Carolina’s last three outings have ended with an average of 46.7 points scored. That’s 4.2 more points than this contest’s over/under.

Oklahoma vs. South Carolina key players

Oklahoma Sooners

• John Mateer leads Oklahoma with 1,417 yards (283.4 ypg) on 115-of-179 passing with six touchdowns and six interceptions this season. He also has 195 rushing yards on 57 carries while scoring five touchdowns on the ground.
• Tory Blaylock has racked up 292 yards on 68 carries while finding the end zone three times as a runner.
• Isaiah Sategna’s leads his squad with 420 yards as a receiver. He’s racked up that yardage on 30 receptions (out of 45 targets) and scored three touchdowns.
• Jaren Kanak has reeled in 23 passes while averaging 58.0 yards per game.
• Deion Burks’ 30 grabs have yielded 339 yards and two touchdowns.
• R Mason Thomas has 4.0 sacks to pace the team, and also has 3.0 TFL and 14 tackles.
• Oklahoma’s leading tackler, Kip Lewis, has 17 tackles, 1.0 TFL, and 0.5 sacks this year.
• Jaydan Hardy leads the team with one interception, while also putting up three tackles and one pass defended.

South Carolina Gamecocks

• LaNorris Sellers has thrown for 1,010 yards (168.3 ypg) while completing 64% of his passes and recording four touchdown passes with two interceptions this season. He’s also run for 117 yards with one touchdown.
• The team’s top rusher, Rahsul Faison, has carried the ball 54 times for 231 yards (38.5 per game) with three touchdowns.
• Matthew Fuller has been given 33 carries and totaled 154 yards with two touchdowns.
• Vandrevius Jacobs has hauled in 341 receiving yards on 20 catches to pace his squad so far this season while scoring two touchdowns as a receiver.
• Nyck Harbor has collected 256 receiving yards (42.7 yards per game) and one touchdown on 13 receptions.
• Donovan Murphree has racked up 94 reciving yards (23.5 ypg) this season.
• Dylan Stewart has collected 4.0 sacks to lead the team, while also recording 8.0 TFL and 26 tackles.
• South Carolina’s leading tackler, DQ Smith, has 29 tackles and one interception this year.
• Peyton Williams has picked off a team-leading two passes. He also has 20 tackles and two passes defended to his name.