The No. 6 Oregon Ducks (9-1) and the No. 16 USC Trojans (8-2) square off on Saturday, November 22, 2025 at Autzen Stadium in a clash of Big Ten foes.

The Ducks are expected to win by double digits (currently -10.5) versus the Trojans. The over/under for this matchup is 59.5 points.

Keep reading for our betting preview for this this matchup between the Ducks and the Trojans, and discover all of our predictions here, too!

Oregon vs. USC betting lines

• Spread favorite: Ducks (-10.5)
• Moneyline: Ducks (-408), Trojans (+316)
• Total: 59.5 points
• TV Channel: CBS (KTVQ – Billings)
• Live Stream: Fubo

Oregon vs. USC betting info and stats

Oregon has a 5-5-0 record against the spread this season. Oregon has covered the spread four times when favored by 10.5 or more points this season (4-3 ATS). Oregon is 7-1 in the eight games this season it has been moneyline favorites. USC is 5-5-0 against the spread through 10 opportunities so far this season. When USC is an underdog of 10.5 points or more, it has always covered the spread (1-0 ATS). This will be the second time this year USC is the moneyline underdog. The Trojans lost the first one.

Oregon vs. USC recent stats and trends

Oregon Ducks

• Oregon is 1-2 against the spread in its past three games, and has a 3-0 straight-up record in those contests.
• The final combined score of the past three Oregon games surpassed the set total once.
• The last three Oregon games averaged 43.8 total points, 15.7 fewer points than this matchup’s over/under.

USC Trojans

• USC has covered the spread once in its last three contests while putting together a 3-0 record straight-up in those games.
• In one of those three games, the final combined score went over the set total.
• USC’s past three games have ended with an average of 53.8 points scored. That’s 5.7 fewer points than this contest’s over/under.

Oregon vs. USC key players

Oregon Ducks

• Dante Moore has thrown for 2,190 yards (219.0 ypg) to lead Oregon, completing 72.8% of his passes and collecting 21 touchdown passes compared to five interceptions this season. He’s also figured in the ground game with 183 rushing yards on 48 carries.
• Noah Whittington has racked up 623 yards on 76 carries while finding paydirt five times.
• Jordon Davison has been handed the ball 65 times this year and racked up 461 yards (46.1 per game) with 12 touchdowns.
• Dakorien Moore’s leads his squad with 443 yards as a receiver. He’s racked up that yardage on 28 catches (out of 43 targets) and scored three touchdowns.
• Kenyon Sadiq has hauled in 30 receptions totaling 407 yards, finding the end zone six times as a receiver so far this campaign.
• Malik Benson has a total of 357 receiving yards so far this year, grabbing 22 throws and scoring three touchdowns.
• Teitum Tuioti has 5.5 sacks to pace the team, and also has 7.0 TFL and 47 tackles.
• Bryce Boettcher, Oregon’s top tackler, has 72 tackles, 1.0 TFL, one sack, and one interception this year.
• Jerry Mixon has picked off a team-leading two passes. He also has 38 tackles, 1.0 TFL, 0.5 sacks, and two passes defended to his name.

USC Trojans

• Jayden Maiava has recored 2,868 passing yards, or 286.8 per game, so far this season. He has completed 66.8% of his passes and has recorded 18 touchdowns with six interceptions. He’s also helped out on the ground with 12.4 rushing yards per game while scoring as a runner six times.
• The team’s top rusher, King Miller, has carried the ball 99 times for 719 yards (89.9 per game) with five touchdowns.
• Waymond Jordan has piled up 88 carries and totaled 576 yards with five touchdowns.
• Makai Lemon has collected 71 receptions this season and his team-high yardage total sits at 1,090 (109.0 yards per game). He’s been targeted 88 times and has eight touchdowns.
• Ja’Kobi Lane has put up a 585-yard season so far with four touchdowns. He’s caught 40 passes on 59 targets.
• Lake McRee’s 24 receptions (on 44 targets) have netted him 389 yards (38.9 ypg) and two touchdowns.
• Braylan Shelby has racked up 3.5 sacks to lead the team, while also recording 4.0 TFL, 13 tackles, and one interception.
• Desman Stephens II is the team’s tackle leader this year. He’s racked up 41 tackles.
• Bishop Fitzgerald leads the team with five interceptions, while also putting up 31 tackles, 2.0 TFL, one sack, and five passes defended.